Working… Menu

Aortic Elongation and Dissection

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02722889
Recruitment Status : Completed
First Posted : March 30, 2016
Last Update Posted : March 22, 2017
Information provided by (Responsible Party):
Maastricht University Medical Center

Brief Summary:
Aim of this study is to measure length of the ascending aorta in adults and to investigate the clinical implication of 'elongation' of the aorta.

Condition or disease
Thoracic Aorta

Detailed Description:
Regarding to aortic geometry, attention is often drawn to aortic diameters since an increase in these diameters (e.g. aneurysm) can lead to life-threatening complications such as dissection and/or rupture. In daily practice however (e.g. imaging reports), the investigators often encounter patients with elongation of the ascending aorta. Little is known about the length of the proximal aorta. Furthermore, the clinical implications of an elongated aorta are unknown.

Layout table for study information
Study Type : Observational
Actual Enrollment : 298 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Ascending Aortic Length in Relation to Age and the Occurrence of Type A Aortic Dissection
Actual Study Start Date : March 2016
Actual Primary Completion Date : December 2016
Actual Study Completion Date : January 2017

Healthy controls
Healthy control patients
Type A dissection
Patients with proven type A dissection,

Primary Outcome Measures :
  1. Length of the ascending aorta [ Time Frame: Up to 72 months ]
    Ascending aortic length as measured on computed tomography.

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

Layout table for eligibility information
Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Reference group to assess 'normal' aortic length.

Inclusion Criteria:

  • Underwent recent (<6 years) contrast-enhanced CT scan which allows for segmentation and assessment of aortic geometry.

Exclusion Criteria:

  • Age <18 years old.
  • Prior thoracic, cardiac or aortic surgery.
  • Genetic disease with cardiac and/or aortic involvement (e.g. Marfan's disease).
  • Infectious disease of the aorta.
  • Malignant disease with involvement of heart and/or aorta.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02722889

Layout table for location information
Maastricht University Medical Center
Maastricht, Limburg, Netherlands, 6202AZ
Sponsors and Collaborators
Maastricht University Medical Center
Layout table for investigator information
Principal Investigator: Joachim Wildberger, MD, PhD Head of department of Radiology
Layout table for additonal information
Responsible Party: Maastricht University Medical Center Identifier: NCT02722889    
Other Study ID Numbers: 16-4-027
First Posted: March 30, 2016    Key Record Dates
Last Update Posted: March 22, 2017
Last Verified: March 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Maastricht University Medical Center:
Ascending aorta
Elongation of the aorta
Type A dissection
Aortic rupture
Aortic length