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Dual Energy CT: A New Method for Better Dose Calculation in Proton Beam Therapy ((DUAL))

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ClinicalTrials.gov Identifier: NCT02722109
Recruitment Status : Terminated (Not enough patients signed up)
First Posted : March 29, 2016
Last Update Posted : January 10, 2018
Sponsor:
Information provided by (Responsible Party):
Vicki Trier Taasti, Aarhus University Hospital

Brief Summary:
Researchers want to compare proton stopping ratios, used for proton beam therapy planning, calculated based on single energy CT and dual energy CT images; with the intension of improve upon the proton range determination.

Condition or disease Intervention/treatment
Cancer Other: No intervention

Detailed Description:

The main goal of this study is to compare proton stopping ratios, used for proton beam therapy planning, calculated based on single energy CT and dual energy CT images.

The calculation methods for proton stopping power ratios differs for the two types of CT images, and researchers want to investigate if the proton stopping power ratio can be estimated more accurately by using dual energy CT. A more accurate stopping power ratio calculation gives a more accurate proton range determination in the patient tissue, which again will lead to a better knowledge of the dose distribution in the patient undergoing cancer treatment with proton beam irradiation.

Knowing the accurate dose distribution allows for an uncertainty margin reduction around the tumor, which will result in less normal tissue being irradiated and thereby the risk of side effects is reduced without risking an under-dosage of the tumor.


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Study Type : Observational
Actual Enrollment : 14 participants
Observational Model: Other
Time Perspective: Other
Official Title: Dual Energy CT: A New Method for Better Dose Calculation in Proton Beam Therapy
Actual Study Start Date : August 2016
Actual Primary Completion Date : December 2017
Actual Study Completion Date : December 2017

Intervention Details:
  • Other: No intervention
    No intervention will be done


Primary Outcome Measures :
  1. Stopping power ratio differences [ Time Frame: 2 months ]

    For each patient the stopping power will be calculated based on both single and dual energy CT. The treatment of the patient will not be affected in any way of this study, the patient will receive the same treatment whether or not the patient volunteers to participate in this study. And the outcome of the calculations performed in this study will have no influence for the patient.

    The calculations of the stopping power differences for each patient will as far as possible be done right after acquisition of the CT images, but the exact time point is not important. We will set as a deadline that the calculation for each patient is done within 2 months of acquisition of the CT images of the patient.

    The entire study will be finished within 2 years, and the results will be tried published in a peer-reviewed journal.




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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
  • Patients with a identified tumor referred to curativ intended external beam radiotherapy
  • Patients, for who are scheduled for a control CT scan during their treatment course
  • Patients above 18 years of age
  • Participation will take place on a voluntary basis It is estimated that annually around 1,000 patients will meet the above inclusion criteria
Criteria

Inclusion Criteria:

  • Cancer patients who are scheduled for a control CT scan

Exclusion Criteria:

  • Under 18 years of age

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02722109


Sponsors and Collaborators
Aarhus University Hospital
Investigators
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Study Director: Cai Grau, Professor Aarhus University Hospital

Publications of Results:
Other Publications:
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Responsible Party: Vicki Trier Taasti, M.Sc., PhD student, Aarhus University Hospital
ClinicalTrials.gov Identifier: NCT02722109     History of Changes
Other Study ID Numbers: VEK52217
First Posted: March 29, 2016    Key Record Dates
Last Update Posted: January 10, 2018
Last Verified: January 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Plan Description: There is no plan to share data with other centers