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Processing Integration in Neurological Patients Using fMRI

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ClinicalTrials.gov Identifier: NCT02722070
Recruitment Status : Not yet recruiting
First Posted : March 29, 2016
Last Update Posted : March 29, 2016
Sponsor:
Information provided by (Responsible Party):
Hadassah Medical Organization

Brief Summary:
The main objective of the study is to explore and map brain areas involved in processing and perception in patients suffering from neurological pathologies and condition. The investigators hypothesize for example, that a change (compare to healthy subjects) in the perceptual maps and body representation could be detected and characterize in patients suffering from impairments of peripheral nerve conduction.

Condition or disease Intervention/treatment
Acute Inflammatory Demyelinating Polyradiculoneuropathy Stroke Anosognosia Central and Peripheral Neurodegenerative Pathologies Neuropsychiatric Conditions Device: 3 Tesla Siemens Skyra MRI scanner

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Study Type : Observational
Estimated Enrollment : 150 participants
Observational Model: Cohort
Time Perspective: Cross-Sectional
Official Title: Processing Integration in Neurological Patients Using fMRI
Study Start Date : March 2016
Estimated Primary Completion Date : March 2020
Estimated Study Completion Date : March 2025

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Healthy Controls
Age matched control for the various clinical groups
Device: 3 Tesla Siemens Skyra MRI scanner
Standardly used Magnetic resonance imaging (MRI) protocols, including resting state fMRI, task fMRI, T1 weighted imaging

Neurodegenerative patients Device: 3 Tesla Siemens Skyra MRI scanner
Standardly used Magnetic resonance imaging (MRI) protocols, including resting state fMRI, task fMRI, T1 weighted imaging

Stroke patients Device: 3 Tesla Siemens Skyra MRI scanner
Standardly used Magnetic resonance imaging (MRI) protocols, including resting state fMRI, task fMRI, T1 weighted imaging

Neuropsychiatric patients Device: 3 Tesla Siemens Skyra MRI scanner
Standardly used Magnetic resonance imaging (MRI) protocols, including resting state fMRI, task fMRI, T1 weighted imaging




Primary Outcome Measures :
  1. Hemodynamic responses by measurement of the Blood-oxygen-level dependence(BOLD) signal [ Time Frame: 2 years ]
    Distinct maps of sensory and multisensory representations related to certain disorders will be sassed by measurement of the Blood-oxygen-level dependence(BOLD) signal.



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Ages Eligible for Study:   18 Years to 85 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Patients suffering from central and peripheral neurological pathologies and conditions
Criteria

Inclusion Criteria:

  • diagnosis of the investigated neuronal disease

Exclusion Criteria:

  • contraindication for MRI scan
  • pregnancy
  • refusal to participate in the study

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02722070


Contacts
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Contact: Shahar Arzy, M.D, Ph.D 97226777741 shahar.arzy@gmail.com
Contact: Gregory Founshtein, M.s 972507794574 gregory.founshtein@mail.huji.ac.il

Sponsors and Collaborators
Hadassah Medical Organization

Publications of Results:
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Responsible Party: Hadassah Medical Organization
ClinicalTrials.gov Identifier: NCT02722070     History of Changes
Other Study ID Numbers: 0657-15-HMO-CTIL
First Posted: March 29, 2016    Key Record Dates
Last Update Posted: March 29, 2016
Last Verified: January 2016
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Additional relevant MeSH terms:
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Guillain-Barre Syndrome
Polyradiculoneuropathy
Agnosia
Autoimmune Diseases of the Nervous System
Nervous System Diseases
Demyelinating Diseases
Polyneuropathies
Peripheral Nervous System Diseases
Neuromuscular Diseases
Autoimmune Diseases
Immune System Diseases
Perceptual Disorders
Neurobehavioral Manifestations
Neurologic Manifestations
Signs and Symptoms