Investigating Neuroimaging Endophenotypes for Autism Spectrum Disorder
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|ClinicalTrials.gov Identifier: NCT02720588|
Recruitment Status : Unknown
Verified March 2016 by National Taiwan University Hospital.
Recruitment status was: Recruiting
First Posted : March 28, 2016
Last Update Posted : March 28, 2016
|Condition or disease|
|Autism Spectrum Disorder|
Autism spectrum disorder (ASD) is a highly heritable neurodevelopmental disorder, yet the search for genes with a definitive role in its etiology has remained elusive. Deconstructing the disorder with endophenotypic approach should boost the statistical power of genetic studies and clarify the pathophysiology of autism. Neuroimaging data provides evidence for atypical trajectories of brain growth in ASD, which result in differences in neuroanatomy and connectivity in the widespread neural systems. As genetic factors are responsible for a significant amount of variation in neuroanatomy and intrinsic functional connectivity, shared alterations in brain morphology and associated functional connectivity between individuals with ASD and their unaffected siblings is likely a useful endophenotype. Nonetheless, such multi-modal approach has never been tested in study on endophenotypic markers for ASD. The study aims to fill in the gap.
The investigators plan to recruit 90 participants (30 adults with ASD, 30 unaffected siblings, and 30 healthy controls), without current and past history of any systemic physical illness, neither any major psychiatric disorder other than ASD. All the participants will receive psychiatric interviews (the Chinese version of the Autism Diagnostic Interview-Revised, ADI-R; the Chinese Version of the Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia, K-SADS-E). They will receive the Wechsler Adult Intelligence Scale-3rd edition(WAIS-III) first to ensure their full-scale IQ greater than 70. The MRI assessments (T1 imaging, single-echo echo planar imaging(EPI) resting-state fMRI) will be subsequently arranged within 2 weeks after psychiatric/neuropsychological assessments.
The investigators anticipate that this study (1) will be the first report in Taiwan to report neuroimaging endophenotypes for ASD; (2) will be the first report in the world on the shared structural and functional connective differences by ASD and their unaffected siblings; (3) will provide further evidence about the mechanism underpinning the broad autism phenotype.
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||Investigating Neuroimaging Endophenotypes for Autism Spectrum Disorder|
|Study Start Date :||January 2016|
|Estimated Primary Completion Date :||December 2016|
Subjects have a clinical diagnosis of autistic disorder or Asperger disorder defined by the DSM-IV criteria
Sex-matched unaffected siblings of ASD probands
Typically developing controls without lifetime ASD or a family history of ASD
- Psychiatric Interview [ Time Frame: 1 hour ]Subjects will be interviewed by Chinese Version of the Kiddie Epidemiologic version of the Schedule for Affective Disorders and Schizophrenia (K-SADS-E)
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02720588
|Contact: Hsiang-Yuan Lin, MD||886-2-23123456 ext email@example.com|
|National Taiwan Univeristy Hospital||Recruiting|
|Contact: Susan Shur-Fen Gau, MD, PhD 886-2-23123456 ext 66802 firstname.lastname@example.org|
|Principal Investigator:||Hsiang-Yuan Lin, MD||Dept of Psychiatry, National Taiwan University Hospital|
|Study Director:||Susan Shur-Fen Gau, MD, PhD||National Taiwan University Hospital & College of Medicine|