Magnetic Resonance Imaging-based Comparative Research in Different Mild Cognitive Impairment Subtype
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|ClinicalTrials.gov Identifier: NCT02706210|
Recruitment Status : Unknown
Verified March 2016 by Yang Yu, Mudanjiang Medical University.
Recruitment status was: Recruiting
First Posted : March 11, 2016
Last Update Posted : March 1, 2017
|Condition or disease|
|Mild Cognitive Impairment|
The investigators use both psychological tests and neuroimage to compare the differences between the two groups.
All the participants received a battery of neuropsychological tests to assess general mental status and other cognitive domains, including visual-spatial ability, executive function, language, memory, attention, and general intellectual ability. These tests included the CDR scale, the Mini-Mental State Examination(MMSE), the Montreal Cognitive Assessment(MoCA), clock drawing test (CDT), Auditory Verbal Learning Test (AVLT), activities of daily living scale(ADL) and Hamilton Depression Scale and HIS. All these evaluations were performed by two attending neurologists.
All participants were scanned on a 3.0 T Siemens scanner within a single session.
Each participant received a magnetization prepared rapidly acquired gradient echo (MPRAGE) T1-weighted scan (repetition time [TR], 1900 ms; echo time [TE], 2.2 ms; inversion time, 900 ms; matrix, 256×256; number of excitations, 1; thickness, 1 mm; 176 slices) Resting state functional images were collected using an echo-planar imaging (EPI) sequence with the following parameters: repetition time (TR)= 2000 ms; echo time (TE)=40 ms; flip angle=90°; number of slices=28; slice thickness=4 mm; gap=1 mm; voxel size=4×4×4 mm3; and matrix=64×64. Participants were asked to lie quietly in the scanner with their eyes closed during the data acquisition. This scan lasted for 478 s. For each subject, the first five volumes were discarded to allow for T1 equilibration effects and the adaptation of the subjects to the circumstances, leaving 234 images for further analysis.
The diffusion weighted imaging scans were acquired on a 3.0T Siemens Tim Trio MRI scanner. Three diffusion echo-planar imaging sequence with one zero-weighted image (b =0 s/mm2) and thirty diffusion sensitizing orientations (b =1000 s/mm2) was used with the following specifications: slice thickness=2 mm; 90 slices; repetition time = 11000 ms; echo time = 98 ms; voxel size = 2 mm isotropic; flip angle=90°; acquisition matrix = 128 mm×116 mm .
|Study Type :||Observational|
|Estimated Enrollment :||160 participants|
|Actual Study Start Date :||September 2015|
|Estimated Primary Completion Date :||June 2017|
|Estimated Study Completion Date :||December 2018|
|vascular cognitive disorders pre-dementia (VCD-P)|
|amnestic mild cognitive impairment (aMCI)|
- fractional anisotropy (FA) [ Time Frame: about 3-5 years after they had a complaint of cognitive deficit ]The diffusion tensor matrix would be generated from a series of diffusion weighted images, then the three eigenvalues or diffusivities, would be calculated by matrix diagonalization. FA represents the degree of anisotropy of the diffusion of water molecules in axons and decreased FA is a frequent correlate of brain tissue injury. It is a DTI parameter without units.
- axial diffusivity (AxD) [ Time Frame: about 3-5 years after they had a complaint of cognitive deficit ]AxD represents the water diffusivity parallel to the axonal fibers, and therefore commonly linked to the microstructure of myelin. It is a DTI parameter without units.
- radial diffusivity (RD) [ Time Frame: about 3-5 years after they had a complaint of cognitive deficit ]RD components of the diffusion metric provide indices of axonal integrity, measured as longitudinal diffusivity, and myelin integrity. It is a DTI parameter without units.
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02706210
|Contact: Changhao Yin||86 email@example.com|
|Department of Neurology, Hongqi Hospital of Mudanjiang Medical Universiy||Recruiting|
|Mudanjiang, Heilongjiang, China|
|Contact: Changhao Yin|