Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults (HT)
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ClinicalTrials.gov Identifier: NCT02706093 |
Recruitment Status :
Recruiting
First Posted : March 11, 2016
Last Update Posted : January 21, 2019
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The overall objectives are to:
- Assess mechanisms underlying HIIT-induced improvements in insulin resistance at the whole-body, tissue, and cellular levels.
- Systematically compare different HIIT regimens to help identify effective "doses" of HIIT that may be optimal for improving metabolic health in obese adults.
- Assess the ability/willingness of obese subjects to adhere to a long-term HIIT program.
Findings from these studies will greatly expand knowledge about the effects of HIIT on metabolic health, and will provide valuable information for development of programs aimed at maximizing key metabolic benefits of exercise.
Condition or disease | Intervention/treatment | Phase |
---|---|---|
Glucose Intolerance | Other: High Intensity Interval Training #1 Other: Moderate intensity continuous training Other: High Intensity Interval Training #2 Other: High Intensity Interval Training #3 | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 120 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Prevention |
Official Title: | Metabolic Adaptations in Response to High Intensity Interval Training in Obese Adults |
Study Start Date : | March 2016 |
Estimated Primary Completion Date : | January 2020 |
Estimated Study Completion Date : | January 2025 |
Arm | Intervention/treatment |
---|---|
High Intensity Interval Training #1
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
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Other: High Intensity Interval Training #1
(HIIT#1) 10 x 1 min. at ~90%HRmax - with low intensity warm-up, recovery, and cool down - total of 25 min/session . |
Moderate intensity continuous training
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
|
Other: Moderate intensity continuous training
Moderate-intensity continuous training (MICT) = steady-state exercise at 60-70%HRmax for 45min. Representing a commonly prescribed exercise program. |
High Intensity Interval Training #2
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
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Other: High Intensity Interval Training #2
(HIIT #2) 5 x 1 min at 90%HRmax + 10 min steady-state exercise at 70%HRmax [25min; ~150kcals; 4d/wk] |
High Intensity Interval Training #3
Obese adults with impaired glucose tolerance will be randomized into one of four different exercise training groups for a 3 month exercise intervention.
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Other: High Intensity Interval Training #3
(HIIT #3) 5 x 1 min at 90%HRmax [15min; ~90kcals; 4d/wk] |
- Insulin Sensitivity [ Time Frame: Change from Baseline at 3 months ]A hyperinsulinemic-euglycemic clamp will be used to assess peripheral insulin sensitivity
- Continuous Glucose Monitoring [ Time Frame: Change from Baseline at 3 months ]
- Resting Metabolic Rate [ Time Frame: baseline and 3 months ]
- Muscle Biopsy [ Time Frame: Change from Baseline at 3 months ]To measure Mitochondrial Proteins
- Adipose Tissue Biopsy [ Time Frame: Change from Baseline at 3 months ]To measure cytokines

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Ages Eligible for Study: | 18 Years to 40 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Age: 18-40
- Body Mass Index: 30-40 kg/m2
- Waist circumference: 88-98cm for women and 100-110cm for men
- Glucose intolerant (i.e., 2h glucose concentration during a screening oral glucose tolerance test (OGTT)= 140-199mg/dl
- No regularly planned exercise/physical activity
- Women must have regularly occurring menses and must be premenopausal
Exclusion Criteria:
- EKG abnormalities as assessed by the cardiologist on the research team
- Evidence/history of cardiovascular or metabolic disease
- Medications known to affect lipid or glucose metabolism
- Pregnant or lactating
- Tobacco or e-cigarette use

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02706093
Contact: Suzette Howton | 734-647-9850 | suzetter@med.umich.edu |
United States, Michigan | |
Suzette Howton | Recruiting |
Ann Arbor, Michigan, United States, 48178 | |
Contact: Suzette Howton 734-647-9850 suzetter@med.umich.edu | |
Principal Investigator: jeff Horowitz |
Principal Investigator: | Jeff Horowitz | University of Michigan |
Responsible Party: | Jeffrey F Horowitz, Professor, Movement Science and Director, Substrate Metabolism Laboratory, University of Michigan |
ClinicalTrials.gov Identifier: | NCT02706093 History of Changes |
Other Study ID Numbers: |
HUM00106883 |
First Posted: | March 11, 2016 Key Record Dates |
Last Update Posted: | January 21, 2019 |
Last Verified: | January 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Additional relevant MeSH terms:
Glucose Intolerance Hyperglycemia Glucose Metabolism Disorders Metabolic Diseases |