Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination
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|ClinicalTrials.gov Identifier: NCT02704936|
Recruitment Status : Recruiting
First Posted : March 10, 2016
Last Update Posted : August 22, 2017
|Condition or disease|
Analyze lipid profiles in samples of sperm and seminal plasma of three populations:
- male sperm donors
- men assigned to a program of assisted reproduction with normal sperm / slightly abnormal successfully in the IUI;
- attached to a program of assisted reproduction with male semen Normal / slightly abnormal unsuccessfully in IUI
Establish partnerships between the composition of fatty acids, especially fatty acids polyunsaturated (PUFA) of the omega-3 (w3) series of samples analyzed parameterssemen and results of the IA to identify biochemical markers of fertility.
Assess markers found by checking the increase in the rate of success in the IA.
|Study Type :||Observational|
|Estimated Enrollment :||126 participants|
|Official Title:||Analysis of Lipid Profiles in Samples Sperm and Seminal Plasma Under Artificial Insemination|
|Study Start Date :||December 2015|
|Estimated Primary Completion Date :||October 2018|
|Estimated Study Completion Date :||December 2018|
42 samples of semen from male donor attached to a donation program Normal sperm count as WHO 2010.
IUI positive pregnancy
42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and have obtained positive pregnancy in any of the first 4 treatments IUI
IUI unsuccessful pregnancy
42 samples of semen from a program attached to patients for insemination Male indication Normal / slightly abnormal sperm count or infertility source unknown and after undergoing maximum 4 cycles have unsuccessfully IUI indication of IVF / ICSI.
- Identify, by Lipidomics approaches, biochemical markers of fertility / infertility sperm and seminal plasma linking the success or failure of the artificial insemination [ Time Frame: 18 months ]
Levels of docosahexaenoic acid (DHA) and acid eicosapentaenoic (EPA) in 42 semen samples:
- With positive pregnancy in any of the first 4 treatments of artificial insemination.
- Gestacion Negative in artificial insemination
- Assigned to the program-donors donation
- Descriptive analysis of semen parameters versus DHA and EPA levels [ Time Frame: 18 months ]
Correlation analysis of seminal variables:
sperm count, motility and morphology percent compared to the levels of DHA and EPA obtained.
Assuming normal distribution continuous variables, ANOVA test apply. If the normality assumption failed an Kruskal-Wallis test was applied.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02704936
|Contact: Fernando Quintana, MD||+34 944806020 ext firstname.lastname@example.org|
|Contact: Marcos PI Ferrando, MD||+34 944806020 ext email@example.com|
|Leioa, Vizcaya, Spain, 48940|
|Contact: Fernando Quintana +34 944806020 ext 20504 firstname.lastname@example.org|
|Contact: Marcos Ferrando +34 944 806020 ext 20503 email@example.com|
|Principal Investigator:||Marcos Ferrando, MD||IVI Bilbao|