The Influence of AMH on Ovarian Responsiveness to Ovulation Induction With GnRH in Women With PCOS
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|ClinicalTrials.gov Identifier: NCT02673632|
Recruitment Status : Unknown
Verified February 2016 by Ahmed Mohamed Bahaa Eldin Ahmed, Ain Shams Maternity Hospital.
Recruitment status was: Not yet recruiting
First Posted : February 4, 2016
Last Update Posted : February 4, 2016
|Condition or disease||Intervention/treatment|
|Infertility||Drug: Merional ®|
There is a correlation between high levels of AMH and the severity of PCOS. Excessive AMH may have a negative effect on the sensitivity of the resting follicles to gonadotropins.
This is an observational prospective study to investigate the impact of circulating AMH on gonadotrophin induction in women with PCOS.
|Study Type :||Observational|
|Estimated Enrollment :||30 participants|
|Official Title:||The Influence of Anti-Müllerian Hormone on Ovarian Responsiveness to Ovulation Induction With Gonadotrophins in Women With Polycystic Ovarian Syndrome|
|Study Start Date :||February 2016|
|Estimated Primary Completion Date :||May 2016|
|Estimated Study Completion Date :||August 2016|
- Drug: Merional ®
Using the long protocol of controlled ovarian hyperstimulation (COH). Down regulation by (Decapeptyl ®, Ferring) 0.1mg subcutaneously once daily starting from day 18 of the preceding cycle, human menopausal gonadotrophin (hMG) (Merional ®, IBSA) 75 IU starting from cycle day two after confirmation of down regulation (thin endometrium, number of follicular activity, E2 < 50 pg/mL). hMG dose is optimized according to age, BMI, antral follicles count (AFC), the local protocol, FSH level and previous response. Usually PCO patients start by 150 IU.Other Name: Decapeptyl ®
- Good response to hMG therapy defined as occurrence of > 3 mature follicles after treatment. [ Time Frame: 30 days ]Good response to hMG therapy defined as occurrence of > 3 mature follicles after treatment.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02673632
|Contact: Karim L Emam, MBBCHfirstname.lastname@example.org|
|Contact: Ahmed M Bahaa eldin, A.Professor||+20 email@example.com|