Preoperative HIIT in Elderly Cancer Patients (eHIITCa)
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ClinicalTrials.gov Identifier: NCT02671617 |
Recruitment Status :
Completed
First Posted : February 2, 2016
Last Update Posted : September 14, 2018
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This randomized control trial will determine the effect of short term high intensity interval training (HIIT) on physical fitness, in an elderly patient group with active cancer, prior to surgical resection.
Half of the recruited patients will act as a control group and the other half will undergo a HIIT protocol.
Condition or disease | Intervention/treatment | Phase |
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Cancer | Other: High intensity interval training (HIIT) | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 40 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Basic Science |
Official Title: | A Randomised Control Trial to Assess Efficacy of Preoperative High Intensity Interval Training in Elderly Patients Scheduled for Oncological Abdominal Surgery |
Study Start Date : | August 2016 |
Actual Primary Completion Date : | July 2018 |
Actual Study Completion Date : | August 2018 |
Arm | Intervention/treatment |
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No Intervention: Control
Control: This group of patients will receive 'current best practice' as per UK NHS recommendations for their specific cancer management prior to surgery.
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Experimental: High intensity interval training
Exercise: Participants in this group will attend 3-4 times per week to complete HIIT training during the period from diagnosis to surgery. High intensity interval training (HIIT) |
Other: High intensity interval training (HIIT)
Preoperative HIIT protocol. |
- VO2AT (VO2 at anaerobic threshold) [ Time Frame: Baseline and 4 weeks ]Change in anaerobic threshold seen during maximal exercise test (pre and post intervention).
- VO2peak [ Time Frame: Baseline and 4 weeks ]Change in peak volume of oxygen consumption during maximal exercise test (pre and post intervention).
- Subjective acceptability of HIIT preoperatively (via questionnaire) [ Time Frame: After 4 weeks of HIIT. ]Assessment of whether our HIIT protocol is acceptable to patients in this age group.
- Muscle protein synthesis rate changes with HIIT. [ Time Frame: Baseline and 4 weeks. ]Assessment of the effect HIIT has on rate of muscle protein synthesis in this group.

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Ages Eligible for Study: | 65 Years and older (Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- Aged over 65 years (no upper age limit).
- Histologically proven, radiologically or direct visualisation leading to high clinical suspicion of cancer.
- Sufficient mobility to be able to exercise on a static exercise bike.
- Ability to give informed consent.
- Ability to travel to RDH to complete the HIIT sessions (may also rely upon dependents/relatives to provide transport).
Exclusion Criteria:
- Adjuvant systemic chemotherapy / radiotherapy treatment for this cancer. Participants with a significant past medical history of:
- Myocardial infarction (within last 6 months)
- Unstable Angina
- Heart failure (NYHA class III/IV)
- Uncontrolled Hypertension (BP>160/100)
- Previous stroke/TIA
- Severe respiratory disease inc. known pulmonary hypertension(>25 mmHg), Forced Expiratory Volume in 1 second <1.5l.
- Brittle asthma / exercise induced asthma
- Known cerebral aneurysm.
- Inclusion in a recent (within 3 months) study which included any form of exercise, taking a drug or ionising radiation.

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02671617
United Kingdom | |
Royal Derby Hospital | |
Derby, Derbyshire, United Kingdom, DE22 3NE |
Principal Investigator: | John Williams, MBChB FRCA PhD | Nottingham University |
Responsible Party: | University of Nottingham |
ClinicalTrials.gov Identifier: | NCT02671617 |
Other Study ID Numbers: |
eHIITCa |
First Posted: | February 2, 2016 Key Record Dates |
Last Update Posted: | September 14, 2018 |
Last Verified: | September 2018 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Plan Description: | No individual patient data will be made available. |
Abdominal Cavity Aged |