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Pre-eclampsia and Biochemical Markers (PET)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02665897
Recruitment Status : Completed
First Posted : January 28, 2016
Last Update Posted : June 9, 2017
Information provided by (Responsible Party):
Ahmed Mohamed Abbas, Assiut University

Brief Summary:

In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.

This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.

Condition or disease
Detection of Preeclampsia Complications

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Study Type : Observational
Actual Enrollment : 90 participants
Observational Model: Case-Control
Time Perspective: Prospective
Official Title: Correlation Between Complications of Pre-eclampsia and Detection of Novel Biochemical Markers
Actual Study Start Date : January 2016
Actual Primary Completion Date : December 2016
Actual Study Completion Date : May 2017

Resource links provided by the National Library of Medicine

pregnant women with eclampsia will be diagnosed by the occurrence of seizures on top of preeclampsia.
severe preeclampsia
pregnant women with severe preeclampsia will be diagnosed according to blood pressure ≥160/110 mmHg with proteinuria detection by boiling method +3,+4.
matched normotensive pregnant women.

Primary Outcome Measures :
  1. The level of circulating NGAL [ Time Frame: 24 hours ]

Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Pregnant women after 20 weeks

Inclusion Criteria:

  • Age 20-40 years.
  • Gestational age >20 weeks.

Exclusion Criteria:

  • Patients with preexisting renal disease,hypertension, diabetes mellitus, gestational hypertension.
  • Patients Refuse to participate in the study
  • Patients already have complicated preeclampsia.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02665897

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Ahmed Abbas
Assiut, Cairo, Egypt, 002
Sponsors and Collaborators
Assiut University

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Responsible Party: Ahmed Mohamed Abbas, Lecturer, Assiut University Identifier: NCT02665897     History of Changes
Other Study ID Numbers: PET
First Posted: January 28, 2016    Key Record Dates
Last Update Posted: June 9, 2017
Last Verified: June 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Yes
Additional relevant MeSH terms:
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Hypertension, Pregnancy-Induced
Pregnancy Complications