Pre-eclampsia and Biochemical Markers (PET)
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|ClinicalTrials.gov Identifier: NCT02665897|
Recruitment Status : Completed
First Posted : January 28, 2016
Last Update Posted : June 9, 2017
In view of both endothelial injury in pre-eclampsia, high blood pressure and kidney impairment characteristics, a recent study demonstrated that the serum levels of NGAL increased at the end of the second trimester in women who subsequently developed pre-eclampsia compared to the control group.
This correlates well with the endothelial damage that occurs during pre-eclampsia and thus NGAL can be considered as a promising marker in predicting both early and late onset pre-eclampsia. It may be required to combine one or more biomarker with NGAL to increase the precision, and sensitivity for detection of risk and reliability of using biomarkers for pre-eclampsia.
|Condition or disease|
|Detection of Preeclampsia Complications|
|Study Type :||Observational|
|Actual Enrollment :||90 participants|
|Official Title:||Correlation Between Complications of Pre-eclampsia and Detection of Novel Biochemical Markers|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||December 2016|
|Actual Study Completion Date :||May 2017|
pregnant women with eclampsia will be diagnosed by the occurrence of seizures on top of preeclampsia.
pregnant women with severe preeclampsia will be diagnosed according to blood pressure ≥160/110 mmHg with proteinuria detection by boiling method +3,+4.
matched normotensive pregnant women.
- The level of circulating NGAL [ Time Frame: 24 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02665897
|Assiut, Cairo, Egypt, 002|