Cardiopulmonary Exercise Test in Peripheral Arterial Disease
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|ClinicalTrials.gov Identifier: NCT02657278|
Recruitment Status : Completed
First Posted : January 15, 2016
Last Update Posted : January 12, 2018
Aim: To determine whether the lactate threshold during CPET is influenced by the presence of haemodynamically significant PAD.
Assumption: Correction of haemodynamically significant PAD results in an increased LT, measured by CPET.
Design: Prospective study Population: Thirty patients scheduled to undergo surgical or percutaneous treatment of iliofemoral arterial disease for intermittent claudication.
|Condition or disease||Intervention/treatment||Phase|
|Peripheral Arterial Disease||Procedure: Arterial Revascularization surgery or Endovascular procedure||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||31 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Influence of Peripheral Arterial Disease (PAD) on the Onset of Lactate Threshold (LT) in Patients Undergoing Cardiopulmonary Exercise Test (CPET)|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||April 2017|
|Actual Study Completion Date :||April 2017|
Symptomatic Peripheral arterial disease
Patients scheduled to undergo surgery or angioplasty of the iliofemoral segment for intermittent claudication.
Procedure: Arterial Revascularization surgery or Endovascular procedure
Symptoms limited Cardiopulmonary Exercise Test (CPET) performed before and four weeks after surgical or endovascular correction of peripheral arterial disease
- The difference in Lactate Threshold (LT) between the two CPETs [ Time Frame: Four weeks following the intervention ]
- The correlation between rise in LT post treatment (if any) and haemodynamic measures of PAD improvement (ankle-brachial index - ABI - differential). [ Time Frame: Four weeks following the intervention ]
- The effect of the intervention on peak oxygen delivery during exercise. [ Time Frame: Four weeks following the intervention ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02657278
|Liverpool Vascular & Endovascular Service and Department of Respiratory Medicine, Aintree University Hospitals NHS Foundation Trust|
|Liverpool, United Kingdom, L9 7AL|
|Principal Investigator:||Francesco Torella||Aintree University Hospital Foundation Trust|