Cardiopulmonary Exercise Test in Peripheral Arterial Disease
|ClinicalTrials.gov Identifier: NCT02657278|
Recruitment Status : Completed
First Posted : January 15, 2016
Last Update Posted : January 12, 2018
Aim: To determine whether the lactate threshold during CPET is influenced by the presence of haemodynamically significant PAD.
Assumption: Correction of haemodynamically significant PAD results in an increased LT, measured by CPET.
Design: Prospective study Population: Thirty patients scheduled to undergo surgical or percutaneous treatment of iliofemoral arterial disease for intermittent claudication.
|Condition or disease||Intervention/treatment||Phase|
|Peripheral Arterial Disease||Procedure: Arterial Revascularization surgery or Endovascular procedure||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||31 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||The Influence of Peripheral Arterial Disease (PAD) on the Onset of Lactate Threshold (LT) in Patients Undergoing Cardiopulmonary Exercise Test (CPET)|
|Actual Study Start Date :||January 2016|
|Actual Primary Completion Date :||April 2017|
|Actual Study Completion Date :||April 2017|
Symptomatic Peripheral arterial disease
Patients scheduled to undergo surgery or angioplasty of the iliofemoral segment for intermittent claudication.
Procedure: Arterial Revascularization surgery or Endovascular procedure
Symptoms limited Cardiopulmonary Exercise Test (CPET) performed before and four weeks after surgical or endovascular correction of peripheral arterial disease
- The difference in Lactate Threshold (LT) between the two CPETs [ Time Frame: Four weeks following the intervention ]
- The correlation between rise in LT post treatment (if any) and haemodynamic measures of PAD improvement (ankle-brachial index - ABI - differential). [ Time Frame: Four weeks following the intervention ]
- The effect of the intervention on peak oxygen delivery during exercise. [ Time Frame: Four weeks following the intervention ]
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02657278
|Liverpool Vascular & Endovascular Service and Department of Respiratory Medicine, Aintree University Hospitals NHS Foundation Trust|
|Liverpool, United Kingdom, L9 7AL|
|Principal Investigator:||Francesco Torella||Aintree University Hospital Foundation Trust|