Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical Assessment
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|ClinicalTrials.gov Identifier: NCT02656095|
Recruitment Status : Completed
First Posted : January 14, 2016
Last Update Posted : July 11, 2019
This study plans to learn more about measuring Lipoprotein lipase (LPL) activity in humans. LPL is an enzyme in the breakdown of certain types of fats into smaller parts. Lipoprotein lipase deficiency (LPLD) is a very rare genetic disorder in which lipoprotein enzyme is no longer functional. This can cause conditions known as high triglycerides in the blood and inflammation of the pancreas.
Investigational medications to treat LPLD are currently being developed. In order to see if these medications are effective, it is necessary to be able to accurately measure LPL activity in humans.
LPL activity has been successfully measured in animal models after giving heparin. Heparin is a blood thinner which is approved by the FDA. It is originally used to prevent blood clots. This study will administer heparin to healthy adults through intravenous infusion (IV). Blood samples will be collected before and after the infusion to test LDL levels.
The purpose of this study is to develop a cheap, more reliable standard for assessment of LPLD in patients
|Condition or disease||Intervention/treatment|
|Lipoprotein Lipase Deficiency||Drug: Heparin|
|Study Type :||Observational|
|Actual Enrollment :||12 participants|
|Official Title:||Lipoprotein Lipase Enzyme Activity Assay Validation and Clinical Assessment|
|Actual Study Start Date :||March 2016|
|Actual Primary Completion Date :||March 1, 2018|
|Actual Study Completion Date :||March 1, 2018|
- Drug: Heparin
Participants will be given IV heparin in order to release lipoprotein lipase from capillary endothelial cells. Blood will be drawn 10-15 minutes post-heparin administration and run through assay to determine lipoprotein lipase levels.
- Evaluation of Lipoprotein lipase levels [ Time Frame: 10-15 minutes post-heparin adminstration ]Blood will be drawn after IV heparin administration and run through assay to determine lipoprotein lipase levels.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02656095
|Principal Investigator:||Robert Eckel, MD||University of Colorado, Denver|