Preoperative Melatonin or Vitamin C Administration on Postoperative Analgesia
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ClinicalTrials.gov Identifier: NCT02639741 |
Recruitment Status :
Recruiting
First Posted : December 24, 2015
Last Update Posted : February 15, 2019
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Condition or disease | Intervention/treatment | Phase |
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Postoperative Pain | Drug: Melatonin Drug: Vitamin C Other: Placebo | Phase 4 |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 55 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Double (Participant, Investigator) |
Primary Purpose: | Treatment |
Official Title: | Comparison Of The Effects Of Preoperative Melatonin Or Vitamin C Administration On Postoperative Analgesia |
Study Start Date : | November 2014 |
Estimated Primary Completion Date : | December 30, 2019 |
Estimated Study Completion Date : | December 30, 2019 |
Arm | Intervention/treatment |
---|---|
Active Comparator: Oral Melatonin Tablet
Melatonin, Vitamin C and placebo tablet Preoperative single oral dose of melatonin (6 mg) or placebo tablet will be given one hour before the start of anesthesia.
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Drug: Melatonin
Preoperative melatonin tablet will be given and postoperative pain scores will be evaluated
Other Name: Melatonina 3 mg tb, Drug: Vitamin C Preoperative vitamin C tablet will be given and postoperative pain scores will be evaluated
Other Name: Vitamin C 1000 mg tb Other: Placebo Preoperative placebo tablet will be given and postoperative pain scores will be evaluated
Other Name: Placebo tb |
Active Comparator: Oral Vitamin C Tablet
Melatonin, Vitamin C and placebo tablet Preoperative single oral dose of vitamin C (2 gr) or placebo tablet will be given one hour before the start of anesthesia.
|
Drug: Melatonin
Preoperative melatonin tablet will be given and postoperative pain scores will be evaluated
Other Name: Melatonina 3 mg tb, Drug: Vitamin C Preoperative vitamin C tablet will be given and postoperative pain scores will be evaluated
Other Name: Vitamin C 1000 mg tb Other: Placebo Preoperative placebo tablet will be given and postoperative pain scores will be evaluated
Other Name: Placebo tb |
Placebo Comparator: Oral Placebo Tablet
Preoperative single oral dose of placebo tablet will be given one hour before the start of anesthesia.
|
Drug: Melatonin
Preoperative melatonin tablet will be given and postoperative pain scores will be evaluated
Other Name: Melatonina 3 mg tb, Drug: Vitamin C Preoperative vitamin C tablet will be given and postoperative pain scores will be evaluated
Other Name: Vitamin C 1000 mg tb Other: Placebo Preoperative placebo tablet will be given and postoperative pain scores will be evaluated
Other Name: Placebo tb |
- morphine consumption at 24 hours after surgery.) [ Time Frame: 24 hour ]

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Ages Eligible for Study: | 18 Years to 65 Years (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Patients undergoing elective major abdominal surgery with general anesthesia
Exclusion Criteria:
A history of psychiatric disorders, chronic pain syndromes, obstructive sleep apnea, severe asthma, chronic obstructive pulmonary disease, congestive heart failure, hepatic or renal failure, patients with pregnancy or in lactation period or a history of allergic reaction to any drugs

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02639741
Contact: Hakkı Ünlügenç, Prof Dr. | +905336417891 | unlugenc@cu.edu.tr | |
Contact: Hakkı Ünlügenç, Prof Dr. | +903223386742 | hunlugenc@cu.edu.tr |
Turkey | |
Hakkı Ünlügenç | Recruiting |
Adana, Turkey, 01330 | |
Contact: Hakkı Ünlügenç, Prof. Dr. +905336417891 unlugenc@cu.edu.tr |
Study Director: | Hakkı Ünlügenç, Prof Dr. | Cukurova University |
Responsible Party: | Hakki Unlugenc, Clinical Professor, Cukurova University |
ClinicalTrials.gov Identifier: | NCT02639741 |
Other Study ID Numbers: |
HZLTNS99 |
First Posted: | December 24, 2015 Key Record Dates |
Last Update Posted: | February 15, 2019 |
Last Verified: | February 2019 |
Individual Participant Data (IPD) Sharing Statement: | |
Plan to Share IPD: | No |
Melatonin Vitamin C Morphine consumption |
Pain, Postoperative Postoperative Complications Pathologic Processes Pain Neurologic Manifestations Vitamins Ascorbic Acid Melatonin |
Micronutrients Nutrients Growth Substances Physiological Effects of Drugs Antioxidants Molecular Mechanisms of Pharmacological Action Protective Agents Central Nervous System Depressants |