Evaluation and Treatment of Tall Statured Girls (TallgirlsDK)
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|ClinicalTrials.gov Identifier: NCT02638922|
Recruitment Status : Unknown
Verified April 2016 by Anders Juul, Rigshospitalet, Denmark.
Recruitment status was: Active, not recruiting
First Posted : December 23, 2015
Last Update Posted : April 6, 2016
To evaluate the phenotypic characteristics and diagnoses in a large cohort of 304 consecutive girls referred due to tall stature. Furthermore, to evaluate the effect of oral administration of 17β-estradiol on predicted adult height in constitutionally tall statured girls.
A single-centre retrospective observational study of 304 girls evaluated due to tall stature between 1993 and 2013.
Tertiary referral centre for pediatric endocrinology.
A total of 304 girls were evaluated for tall stature of whom 39 (13%) were excluded due to missing data, reclassification, overgrowth syndromes or associated comorbidities. Another 58 (19%) girls did not fulfil auxological criteria for constitutionally tall stature (CTS), resulting in a total of 207 (68%) girls eligible for analysis.
Main Outcome Measures
The effect of oral treatment with 17β-estradiol on height, predicted adult height (PAH), final height and circulating hormones in constitutional tall statured girls.
|Condition or disease||Intervention/treatment|
|Constitutional Tall Stature||Drug: Estradiol|
Show Detailed Description
|Study Type :||Observational|
|Actual Enrollment :||304 participants|
|Observational Model:||Case Control|
|Official Title:||Evaluation of 304 Danish Girls With Tall Stature: Phenotypic Characteristics and Effects of Oral Administration of Natural 17β-Estradiol|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||December 2017|
girls who never received estradiol treatment
girls who received estradiol treatment
Estradiol containing compounds administered orally in a non-randomized manner.
- final height [ Time Frame: 10 year observation time ]attainment of final height
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02638922
|Principal Investigator:||Anders Juul, MD||Rigshospitalet, Denmark|
|Principal Investigator:||Emmie Upners, student||Rigshospitalet, Denmark|