Evaluation and Treatment of Tall Statured Girls (TallgirlsDK)
|ClinicalTrials.gov Identifier: NCT02638922|
Recruitment Status : Unknown
Verified April 2016 by Anders Juul, Rigshospitalet, Denmark.
Recruitment status was: Active, not recruiting
First Posted : December 23, 2015
Last Update Posted : April 6, 2016
To evaluate the phenotypic characteristics and diagnoses in a large cohort of 304 consecutive girls referred due to tall stature. Furthermore, to evaluate the effect of oral administration of 17β-estradiol on predicted adult height in constitutionally tall statured girls.
A single-centre retrospective observational study of 304 girls evaluated due to tall stature between 1993 and 2013.
Tertiary referral centre for pediatric endocrinology.
A total of 304 girls were evaluated for tall stature of whom 39 (13%) were excluded due to missing data, reclassification, overgrowth syndromes or associated comorbidities. Another 58 (19%) girls did not fulfil auxological criteria for constitutionally tall stature (CTS), resulting in a total of 207 (68%) girls eligible for analysis.
Main Outcome Measures
The effect of oral treatment with 17β-estradiol on height, predicted adult height (PAH), final height and circulating hormones in constitutional tall statured girls.
|Condition or disease||Intervention/treatment|
|Constitutional Tall Stature||Drug: Estradiol|
|Study Type :||Observational|
|Actual Enrollment :||304 participants|
|Official Title:||Evaluation of 304 Danish Girls With Tall Stature: Phenotypic Characteristics and Effects of Oral Administration of Natural 17β-Estradiol|
|Study Start Date :||January 2014|
|Estimated Primary Completion Date :||December 2017|
|Estimated Study Completion Date :||December 2017|
girls who never received estradiol treatment
girls who received estradiol treatment
Estradiol containing compounds administered orally in a non-randomized manner.
- final height [ Time Frame: 10 year observation time ]attainment of final height
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02638922
|Principal Investigator:||Anders Juul, MD||Rigshospitalet, Denmark|
|Principal Investigator:||Emmie Upners, student||Rigshospitalet, Denmark|