Predictors of Coronary Artery Calcium Progression in Adults With a Prior Zero Coronary Artery Calcium Score
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|ClinicalTrials.gov Identifier: NCT02636062|
Recruitment Status : Withdrawn (PI - lack of funding)
First Posted : December 21, 2015
Last Update Posted : April 18, 2018
|Condition or disease|
|Coronary Artery Disease Endothelial Dysfunction Atherosclerosis|
|Study Type :||Observational|
|Actual Enrollment :||0 participants|
|Official Title:||Predictors of Coronary Artery Calcium Progression in Adults With a Prior Zero Coronary Artery Calcium Score|
|Estimated Study Start Date :||July 2017|
|Estimated Primary Completion Date :||December 2019|
|Estimated Study Completion Date :||July 2020|
Follow-up CAC > 0
All patients with CAC scores of zero > 5 years previous will be invited to enroll and undergo repeat CAC scanning. This group will include all patients that develop incident CAC.
Follow-up CAC zero
All patients with CAC scores of zero > 5 years previous will be invited to enroll and undergo repeat CAC scanning. This group will include all patients who continue to have a CAC of zero.
- Number of patients with CAC > 0 [ Time Frame: 5 years ]Incident development of any CAC (CAC > 0) between initial scan > 5 years previous and re-scan
- Major adverse cardiovascular events [ Time Frame: 5 years ]The incidence of major adverse cardiovascular events (defined as death from cardiac cause, myocardial infarction, revascularization of obstructive coronary artery disease, stroke, heart failure, and new onset of atrial fibrillation), in all subjects screened for the study between initial CAC scan demonstrating zero CAC and current study screening.
- Per vessel incident CAC [ Time Frame: 5 years ]Individual CAC score for each major epicardial coronary vessel in patients with development of incident CAC > 0
- Number of patients on statin therapy with incident CAC > 0 compared with statin naïve patients [ Time Frame: 5 years ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02636062
|Principal Investigator:||Dustin M Thomas, MD||San Antonio Military Medical Center|