Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine

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ClinicalTrials.gov Identifier: NCT02615314

Recruitment Status : Completed

First Posted : November 26, 2015

Last Update Posted : November 26, 2015

Sponsor:

Information provided by (Responsible Party):

Sertac Yetiser, Anadolu Medical Center

Study Description

Brief Summary:

The aim of this study is to analyze the clinical aspects of patients with BPPV associated with migraine. It is our purpose to clarify weather migraine is a risk factor for BPPV if the clinical aspect and the therapeutic outcome is different.

Condition or disease	Intervention/treatment
Migraine Positional Vertigo	Procedure: Particle re-positioning maneuver

Detailed Description:

Two hundred and sixty-three patients with BPPV were enrolled in this retrospective study. All patients' charts were reviewed by independent observer. The type of BPPV and associated problems were noted. Patients with migraine were investigated in terms of age, gender, symptoms, affected side and the cure rate. Their data were compared with those having no migraine. Mean values and standard deviations (± SD) were calculated. One way ANOVA test was used for the analysis. Significance was set at p < 0.005.

Study Design

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Study Type :	Observational
Actual Enrollment :	232 participants
Observational Model:	Case-Control
Time Perspective:	Cross-Sectional
Official Title:	Clinical Aspects of Patients With Benign Paroxysmal Positional Vertigo (BPPV) and Migraine
Study Start Date :	January 2015
Actual Primary Completion Date :	June 2015
Actual Study Completion Date :	July 2015

Resource links provided by the National Library of Medicine

MedlinePlus Genetics related topics: Migraine

MedlinePlus related topics: Dizziness and Vertigo Migraine

Genetic and Rare Diseases Information Center resources: Benign Paroxysmal Positional Vertigo

U.S. FDA Resources

Groups and Cohorts

Group/Cohort	Intervention/treatment
BPPV without migraine Two hundred and sixty-three patients with BPPV (2009-2014), confirmed by videonystagmography (VNG), were enrolled in the study. Patients' charts were reviewed. They were grouped as those with or without migraine. Distribution of gender, age, duration of symptoms and affected side were reviewed. Two hundred and thirty-one patients with no migraine were identified.	Procedure: Particle re-positioning maneuver Patients with posterior canal BPPV (PC-BPPV) were treated with Epley maneuver. Patients with superior canal (SC-BPPV) were treated with Li or reverse Epley maneuver. Patients with lateral canal (LC) apogeotropic or geotropic nystagmus were treated with Barbeque, Semont's or Gufoni maneuvers. If geotropic or ageotropic type nystagmus is equal intensity on both sides. The involved side was determined according to the patient sense of disturbance or lying down positioning test. If the patient has involvement of both sides according to Dix-Hallpike maneuver. Therapeutic maneuver was applied to the more severe side. All patients were re-evaluated at maximum 7 days.
BPPV with migraine Thirty-two patients (11.4%) with migraine were identified. Diagnosis and classification of migraine and its differentiation from other type of headaches was based on third edition of International classification of headache disorders (ICHD-III beta) by international headache society (IHS). All patients with migraine had migrainous headache with or without aura and they all were diagnosed in our institution and followed by our neurology staff.	Procedure: Particle re-positioning maneuver Patients with posterior canal BPPV (PC-BPPV) were treated with Epley maneuver. Patients with superior canal (SC-BPPV) were treated with Li or reverse Epley maneuver. Patients with lateral canal (LC) apogeotropic or geotropic nystagmus were treated with Barbeque, Semont's or Gufoni maneuvers. If geotropic or ageotropic type nystagmus is equal intensity on both sides. The involved side was determined according to the patient sense of disturbance or lying down positioning test. If the patient has involvement of both sides according to Dix-Hallpike maneuver. Therapeutic maneuver was applied to the more severe side. All patients were re-evaluated at maximum 7 days.

Group/Cohort

Intervention/treatment

BPPV without migraine

Two hundred and sixty-three patients with BPPV (2009-2014), confirmed by videonystagmography (VNG), were enrolled in the study. Patients' charts were reviewed. They were grouped as those with or without migraine. Distribution of gender, age, duration of symptoms and affected side were reviewed. Two hundred and thirty-one patients with no migraine were identified.

Procedure: Particle re-positioning maneuver

Patients with posterior canal BPPV (PC-BPPV) were treated with Epley maneuver. Patients with superior canal (SC-BPPV) were treated with Li or reverse Epley maneuver. Patients with lateral canal (LC) apogeotropic or geotropic nystagmus were treated with Barbeque, Semont's or Gufoni maneuvers. If geotropic or ageotropic type nystagmus is equal intensity on both sides. The involved side was determined according to the patient sense of disturbance or lying down positioning test. If the patient has involvement of both sides according to Dix-Hallpike maneuver. Therapeutic maneuver was applied to the more severe side. All patients were re-evaluated at maximum 7 days.

BPPV with migraine

Thirty-two patients (11.4%) with migraine were identified. Diagnosis and classification of migraine and its differentiation from other type of headaches was based on third edition of International classification of headache disorders (ICHD-III beta) by international headache society (IHS). All patients with migraine had migrainous headache with or without aura and they all were diagnosed in our institution and followed by our neurology staff.

Procedure: Particle re-positioning maneuver

Outcome Measures

Primary Outcome Measures :

Number of patients who had normal vestibular response to provocative tests 7 days after re-positioning maneuver [ Time Frame: 7 days ]
Every patient with BPPV who had positional nystagmus during Dix-Hallpike and head-roll provocative maneuvers will be treated with Epley or barbeque particle re-positioning maneuvers. Balance (positional nystagmus) of patients 7 days after re-positioning maneuvers will be assessed.

Eligibility Criteria

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Ages Eligible for Study:	10 Years to 84 Years (Child, Adult, Older Adult)
Sexes Eligible for Study:	All
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

BPPV patients only confirmed by VNG

Criteria

Inclusion Criteria:

Patients who had history of head-induced positional and brief vertigo and who have been confirmed by VNG were included

Exclusion Criteria:

Patients with balance problem other than BPPV,
Patients receiving any medication prior to therapeutic maneuver were excluded

Contacts and Locations

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02615314

Sponsors and Collaborators

Anadolu Medical Center

Investigators

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Principal Investigator:	Meltem Hale Gokmen, MD	Dept of Neurology, Anadolu Medical Center

More Information

Publications of Results:

Uneri A. Migraine and benign paroxysmal positional vertigo: an outcome study of 476 patients. Ear Nose Throat J. 2004 Dec;83(12):814-5.

Ishiyama A, Jacobson KM, Baloh RW. Migraine and benign positional vertigo. Ann Otol Rhinol Laryngol. 2000 Apr;109(4):377-80.

Yetiser S, Ince D. Demographic analysis of benign paroxysmal positional vertigo as a common public health problem. Ann Med Health Sci Res. 2015 Jan-Feb;5(1):50-3. doi: 10.4103/2141-9248.149788.

von Brevern M, Radtke A, Lezius F, Feldmann M, Ziese T, Lempert T, Neuhauser H. Epidemiology of benign paroxysmal positional vertigo: a population based study. J Neurol Neurosurg Psychiatry. 2007 Jul;78(7):710-5. Epub 2006 Nov 29.

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Responsible Party:	Sertac Yetiser, Clinical Professor, Dept of ORL & HNS, Anadolu Medical Center
ClinicalTrials.gov Identifier:	NCT02615314
Other Study ID Numbers:	AnadoluMC
First Posted:	November 26, 2015 Key Record Dates
Last Update Posted:	November 26, 2015
Last Verified:	November 2015

Keywords provided by Sertac Yetiser, Anadolu Medical Center:


migraine benign paroxysmal positional vertigo

Additional relevant MeSH terms:

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Vertigo Benign Paroxysmal Positional Vertigo Migraine Disorders Dizziness Headache Disorders, Primary Headache Disorders Brain Diseases Central Nervous System Diseases	Nervous System Diseases Vestibular Diseases Labyrinth Diseases Ear Diseases Otorhinolaryngologic Diseases Neurologic Manifestations Sensation Disorders

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