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The Different Analgesic Potency of Volatile Anesthetics at Equi-MAC

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ClinicalTrials.gov Identifier: NCT02609802
Recruitment Status : Completed
First Posted : November 20, 2015
Last Update Posted : November 8, 2017
Sponsor:
Information provided by (Responsible Party):
Kyoungho Ryu, Kangbuk Samsung Hospital

Brief Summary:
The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

Condition or disease Intervention/treatment Phase
Orthopedic Disorders Drug: Sevoflurane Drug: Desflurane Phase 3

Detailed Description:
Volatile anesthetics vary in their relative hypnotic potencies. Recent studies demonstrated that equi-minimum alveolar concentration of various volatile anesthetics produced different EEG-derived indices such as bispectral index. However, there was no controlled study that demonstrates the difference of analgesic potency. The aim of this clinical trial is to evaluate the difference of analgesic potency of sevoflurane and desflurane at equi-minimum alveolar concentration using a surgical pleth index.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 77 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Triple (Participant, Investigator, Outcomes Assessor)
Primary Purpose: Prevention
Official Title: The Different Analgesic Potency of Sevoflurane and Desflurane at Equi-minimum Alveolar Concentration
Study Start Date : November 2015
Actual Primary Completion Date : July 28, 2016
Actual Study Completion Date : July 28, 2016

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Sevoflurane
Anesthesia was maintained with sevoflurane.
Drug: Sevoflurane
Anesthesia was maintained with sevoflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
Other Name: SEVO

Experimental: Desflurane
Anesthesia was maintained with desflurane.
Drug: Desflurane
Anesthesia was maintained with desflurane in patients undergoing arthroscopic shoulder surgery under general anesthesia and interscalene brachial plexus block.
Other Name: DES




Primary Outcome Measures :
  1. Analgesic potency of volatile anesthetics [ Time Frame: the first 60 min of maintaining a steady state 1 MAC of volatile agents ]
    The analgesic potency was evaluated by surgical pleth index value



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Ages Eligible for Study:   19 Years to 65 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • patients undergoing arthroscopic shoulder surgery
  • patients with american society of anesthesiologist physical status I, II
  • patients aged 19-65 years
  • patients obtaining written informed consent

Exclusion Criteria:

  • patients with a history of any psychiatric or neurological disease
  • patients who had received any medication affecting the central nervous system
  • patients who had received medication affecting the sympathetic or parasympathetic nervous systems
  • patients who have not received interscalene approach brachial plexus block (refusal or failure)
  • pregnant women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02609802


Locations
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Korea, Republic of
Kangbuk Samsung Hospital
Seoul, Korea, Republic of, 03181
Sponsors and Collaborators
Kangbuk Samsung Hospital
Investigators
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Principal Investigator: Kyoungho Ryu, M.D. Kangbuk Samsung Hospital

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Responsible Party: Kyoungho Ryu, Clinical assistant professor, Kangbuk Samsung Hospital
ClinicalTrials.gov Identifier: NCT02609802    
Other Study ID Numbers: 2015-09-028
First Posted: November 20, 2015    Key Record Dates
Last Update Posted: November 8, 2017
Last Verified: November 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: Undecided
Additional relevant MeSH terms:
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Musculoskeletal Diseases
Anesthetics
Sevoflurane
Desflurane
Analgesics
Central Nervous System Depressants
Physiological Effects of Drugs
Sensory System Agents
Peripheral Nervous System Agents
Platelet Aggregation Inhibitors
Anesthetics, Inhalation
Anesthetics, General