Uptake and Biodistribution of 18F-fluorocholine in Histiocytic Disorders by PET Imaging and Biopsy Measurement
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|ClinicalTrials.gov Identifier: NCT02608619|
Recruitment Status : Completed
First Posted : November 20, 2015
Last Update Posted : August 29, 2018
|Condition or disease||Intervention/treatment|
|Erdheim-Chester Disease Langerhans Cell Histiocytosis Histiocytic Disorders||Radiation: F-choline PET Scan Device: FDG-PET Procedure: biopsy|
|Study Type :||Observational|
|Actual Enrollment :||3 participants|
|Official Title:||Pilot Study to Determine Uptake and Biodistribution of 18F-fluorocholine in Histiocytic Disorders by PET Imaging and Biopsy Measurement|
|Actual Study Start Date :||November 2015|
|Actual Primary Completion Date :||August 2018|
|Actual Study Completion Date :||August 2018|
This study will enroll patients who have a clinical diagnosis of a systemic histiocytic disorder, and who are scheduled to undergo confirmatory biopsies of the systemic lesions, that were identified by standard imaging modalities.
Radiation: F-choline PET Scan
- percentage of patients who successfully undergo paired biopsies [ Time Frame: 1 year ]The overall histiocyte content will be described in each patient for each paired biopsy: there will be one biopsy that has high 18F-FCH F-choline uptake and one biopsy that has low 18F-FCH F-choline uptake.
Biospecimen Retention: Samples Without DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02608619
|United States, New York|
|Memoral Sloan Kettering Cancer Center|
|New York, New York, United States, 10065|
|Principal Investigator:||Eli Diamond, MD||Memorial Sloan Kettering Cancer Center|