Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood
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|ClinicalTrials.gov Identifier: NCT02607150|
Recruitment Status : Completed
First Posted : November 17, 2015
Last Update Posted : April 7, 2016
A prospective study designed to evaluate changes in tissue and cerebral oxygenation before and following administration of blood for patients undergoing spinal surgery.
Red blood transfusions (autologous and allogeneic) are indicated to improve oxygen delivery to the tissues and hence tissue oxygenation. Despite the presumed efficacy, there are limited data to demonstrate changes in tissue oxygenation with the administration of blood. Furthermore, the administration of both autologous blood from cell saver and allogeneic blood can be associated with both acute and long-term deleterious physiologic effects which may impact the perioperative course. As such, data are needed to clearly delineate the benefits of transfusion during the perioperative period.
|Condition or disease||Intervention/treatment|
|Idiopathic Scoliosis Transfusion Reaction||Other: Cerebral Oxygenation Changes|
|Study Type :||Observational|
|Actual Enrollment :||50 participants|
|Official Title:||Changes in Cerebral Oxygenation During the Administration of Cell Saver Blood and Allogeneic Blood|
|Study Start Date :||December 2014|
|Actual Primary Completion Date :||February 2016|
|Actual Study Completion Date :||March 2016|
- Other: Cerebral Oxygenation Changes
Monitor cerebral oxygenation changes in patients receiving blood transfusions who are undergoing spinal fusion surgery.
- Cerebral Oxygenation Changes [ Time Frame: Intraoperative measure ]To evaluate changes in tissue and cerebral oxygenation during the administration of autologous or allogeneic blood during spinal surgery.
- Oxygenation Changes in Autologous versus Allogeneic Blood Transfusions [ Time Frame: Intraoperative measure ]To determine if there are differences in the changes in tissue and cerebral oxygenation with autologous compared to allogeneic blood.
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02607150
|United States, Ohio|
|Nationwide Children's Hospital|
|Columbus, Ohio, United States, 43205|
|Principal Investigator:||Joseph D. Tobias, MD||Nationwide Children's Hospital|