The CIRE Study (CItrate REcirculation Study) (CIRE)
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|ClinicalTrials.gov Identifier: NCT02600416|
Recruitment Status : Completed
First Posted : November 9, 2015
Last Update Posted : March 30, 2018
|Condition or disease||Intervention/treatment||Phase|
|Acute Kidney Injury||Other: AV port reversal||Not Applicable|
AV port reversal (AVPR) has been demonstrated to increase recirculation in venous catheters used in ICU for CVVH. The effects of this frequently used manoeuvre have not been described in the setting of CVVH using regional citrate anticoagulation.
The aim of this study is to determine the effects of AVPR on recirculation, clearance, post-filter ionized calcium and subsequently citrate dosing.
Study design and methods:
Open trial studying the effect of AVPR in patients undergoing citrate CVVH. After measurement in standard catheter configuration, AVPR is performed after which effects on catheter recirculation, clearance, citrate dosing and post-filter ionized calcium (iCa) are monitored.
Arterial line, arterial (pre-filter) port, postfilter port (after postdilution and calcium compensation), effluent sample. All flow rates to be noted.
Twelve patients admitted to intensive care, requiring continuous renal replacement therapy (CRRT) for AKI. Patients are preferably anuric and have achieved good metabolic control under CVVH before inclusion in the study.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||24 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effects of AV Port Reversal in Citrate CVVH - The CIRE Study (CItrate REcirculation Study)|
|Study Start Date :||December 2015|
|Actual Primary Completion Date :||September 1, 2017|
|Actual Study Completion Date :||September 1, 2017|
AV port reversal
Patients undergoing citrate CVVH.
Other: AV port reversal
Reversal of the AV port at 1h Reversal of the AV port to start position at 7h
- change in citrate concentration in circuit after AV port reversal [ Time Frame: 8 hours ]
- change in post-filter ionised Ca after AV port reversal [ Time Frame: 8 hours ]
- change in clearance after AV port reversal [ Time Frame: 8 hours ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02600416
|Ziekenhuis Oost Limburg|
|Genk, Limburg, Belgium, 3600|
|Principal Investigator:||Willem Boer, MD||Ziekenhuis Oost-Limburg|