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Strength Training Adaptations, Age and Genes (STAGE)

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ClinicalTrials.gov Identifier: NCT02589990
Recruitment Status : Completed
First Posted : October 28, 2015
Last Update Posted : September 28, 2018
Sponsor:
Collaborator:
Norwegian University of Science and Technology
Information provided by (Responsible Party):
Telemark University College

Brief Summary:
The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: Strength training Not Applicable

Detailed Description:

Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.


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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 76 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Effect of Maximal Strength Training in Relation to Age and Genes
Study Start Date : January 2016
Actual Primary Completion Date : August 2018
Actual Study Completion Date : September 3, 2018

Resource links provided by the National Library of Medicine


Arm Intervention/treatment
Experimental: Strength training
Strength training, 4 rep of 4RM x 4 sets in leg press.
Behavioral: Strength training
see arm description




Primary Outcome Measures :
  1. Maximal muscle strength measured by 1 RM leg press in leg press machine [ Time Frame: 8 weeks ]

Secondary Outcome Measures :
  1. Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen [ Time Frame: 8 weeks ]
  2. rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway) [ Time Frame: 8 weeks ]
  3. agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway) [ Time Frame: 8 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Healthy adults 20 to 90 years old

Exclusion Criteria:

  • Contraindications to maximum strength training and testing

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02589990


Locations
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Norway
Telemark University College
Bø, Telemark, Norway, 3800
Norwegian University of Science and Technology
Trondheim, Norway
Sponsors and Collaborators
Telemark University College
Norwegian University of Science and Technology
Investigators
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Study Chair: Øyvind Støren, PhD Telemark University College
Study Director: Mona Sæbø, PhD Telemark University College

Publications:
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Responsible Party: Telemark University College
ClinicalTrials.gov Identifier: NCT02589990     History of Changes
Other Study ID Numbers: STAGE
First Posted: October 28, 2015    Key Record Dates
Last Update Posted: September 28, 2018
Last Verified: September 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Telemark University College:
health
muscle strength
exercise genomics