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Strength Training Adaptations, Age and Genes (STAGE)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02589990
Recruitment Status : Completed
First Posted : October 28, 2015
Last Update Posted : September 28, 2018
Norwegian University of Science and Technology
Information provided by (Responsible Party):
University of South-Eastern Norway

Brief Summary:
The study investigates the effect of maximal strength training on muscular strength and power in different age groups from 20 to 80 year old. It also relates the training adaptations to different known genes such as angiotensin I-converting enzyme (ACE) and Alpha-actinin-3 (ACTN3). Participants will complete an eight weeks, three times per week training intervention of maximal strength training with a pre-post design. In addition, blood samples will be collected for the analyses of genetic variances.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: Strength training Not Applicable

Detailed Description:

Aim: The study aims to investigate the effect of age and genes on training adaptations to a maximal strength training intervention.

Methods: Participants will be recruited through invitations at work places and other community arenas. The investigators aim to recruit 10-15 subjects in each of the following age groups: 20-29, 30-39, 40-49, 50-59, 60-69 and 70-80 years of age. Both genders will be included. All age groups will be matched for age-related baseline maximal strength and distribution between the two genders. All participants will be checked via a health registration scheme, and excluded if contra indications for hard physical training or testing should appear. When in doubt, the projects physician will decide on inclusion or exclusion due to a thorough examination. Subjects will give a blood sample to be analyzed for known genes such as ACE and ACTN3. The intervention has a pre- post design. Tests of maximal strength and power will be conducted in a leg-press machine, using the protocol assessing one repetition maximum (1RM) previously described. Force and Power will be measured by the Muscle Lab system from Ergotest Tech. (Langesund, Norway). The intervention is an eight week, three times per week protocol, each training session consisting of a standardized warm-up, and 4 repetitions x 4 sets with an intensity of 4 repetition maximum (4RM) performed in the leg press machine.There will be a three minutes pause between sets. Participants will be given instructions and supervision.

Hypothesis: Maximal strength training adaptations will be affected by age and baseline maximal strength but not by gender or genetic variations.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 76 participants
Allocation: N/A
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Screening
Official Title: Effect of Maximal Strength Training in Relation to Age and Genes
Study Start Date : January 2016
Actual Primary Completion Date : August 2018
Actual Study Completion Date : September 3, 2018

Resource links provided by the National Library of Medicine

Arm Intervention/treatment
Experimental: Strength training
Strength training, 4 rep of 4RM x 4 sets in leg press.
Behavioral: Strength training
see arm description

Primary Outcome Measures :
  1. Maximal muscle strength measured by 1 RM leg press in leg press machine [ Time Frame: 8 weeks ]

Secondary Outcome Measures :
  1. Blood sample will be collected to assess gene types Alpha Actinin 3, Angiotensin Converting Enzyme, Angiotensinogen [ Time Frame: 8 weeks ]
  2. rate of force development in leg press measured by MuscleLab (Ergotest Tech., Langesund Norway) [ Time Frame: 8 weeks ]
  3. agility will be measured by counter movement jump using the MuscleLab system by Ergotest Tech. (Langesund, Norway) [ Time Frame: 8 weeks ]

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.

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Ages Eligible for Study:   20 Years to 90 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy adults 20 to 90 years old

Exclusion Criteria:

  • Contraindications to maximum strength training and testing

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02589990

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Telemark University College
Bø, Telemark, Norway, 3800
Norwegian University of Science and Technology
Trondheim, Norway
Sponsors and Collaborators
University of South-Eastern Norway
Norwegian University of Science and Technology
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Study Chair: Øyvind Støren, PhD University of South-Eastern Norway
Study Director: Mona Sæbø, PhD University of South-Eastern Norway
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Responsible Party: University of South-Eastern Norway Identifier: NCT02589990    
Other Study ID Numbers: STAGE
First Posted: October 28, 2015    Key Record Dates
Last Update Posted: September 28, 2018
Last Verified: September 2018
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by University of South-Eastern Norway:
muscle strength
exercise genomics