Working…
COVID-19 is an emerging, rapidly evolving situation.
Get the latest public health information from CDC: https://www.coronavirus.gov.

Get the latest research information from NIH: https://www.nih.gov/coronavirus.
ClinicalTrials.gov
ClinicalTrials.gov Menu

Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
 
ClinicalTrials.gov Identifier: NCT02577679
Recruitment Status : Unknown
Verified October 2015 by National Taiwan University Hospital.
Recruitment status was:  Active, not recruiting
First Posted : October 16, 2015
Last Update Posted : October 16, 2015
Sponsor:
Information provided by (Responsible Party):
National Taiwan University Hospital

Brief Summary:
The aim of this case control study is to explore the possible association between periodontal destruction and serum anti-CCP antibodies in RA patients and healthy subjects.

Condition or disease
Periodontitis, Rheumatoid Arthritis, Autoimmunity,

Detailed Description:
In patients with RA, the anti-CCP antibody titer seems positively correlated to their periodontal destruction and disease activity in comparison with healthy subjects.

Layout table for study information
Study Type : Observational
Actual Enrollment : 47 participants
Observational Model: Case Control
Time Perspective: Cross-Sectional
Official Title: Associations Between Periodontitis and Autoimmune Antibodies in Rheumatoid Arthritis Disease
Study Start Date : June 2015
Actual Primary Completion Date : September 2015
Estimated Study Completion Date : November 2015

Resource links provided by the National Library of Medicine





Primary Outcome Measures :
  1. Serum level of anti-cyclic citrullinated peptide/protein antibody [ Time Frame: Base line ]
    Lower then 7 Unit/milliliter: negative 7-10 Unit/milliliter: weak positive Higher then 10 Unit/milliliter: positive

  2. Periodontal pocket depth and clinical attachment level [ Time Frame: Baseline ]
    Lower then 4 millimeter: normal Higher then 4 millimeter: diseased/previously diseased


Secondary Outcome Measures :
  1. Serum level of tumor necrotic factor alpha [ Time Frame: Baseline ]
    Recorded in picogram per milliliter

  2. Serum level of anti-mutated citrullinated vimentin [ Time Frame: Baseline ]
    Recorded in Unit per milliliter

  3. Serum level of interleukin 6 [ Time Frame: Baseline ]
    Recorded in picogram per milliliter

  4. Serum level of interleukin 17 [ Time Frame: Baseline ]
    Recorded in picogram per milliliter



Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Layout table for eligibility information
Ages Eligible for Study:   60 Years to 80 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Physically healthy persons, especially free of any autoimmune diseases, DM, CVD. No history of periodontal treatment.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02577679


Locations
Layout table for location information
Taiwan
National Taiwan University Hospital
Taipei, Taiwan, 100
Sponsors and Collaborators
National Taiwan University Hospital
Investigators
Layout table for investigator information
Study Director: Yi-Wen Chen, PhD Assistant professor
Layout table for additonal information
Responsible Party: National Taiwan University Hospital
ClinicalTrials.gov Identifier: NCT02577679    
Other Study ID Numbers: 201503116RINA
First Posted: October 16, 2015    Key Record Dates
Last Update Posted: October 16, 2015
Last Verified: October 2015
Keywords provided by National Taiwan University Hospital:
Dentistry
Additional relevant MeSH terms:
Layout table for MeSH terms
Arthritis
Arthritis, Rheumatoid
Periodontitis
Joint Diseases
Musculoskeletal Diseases
Rheumatic Diseases
Connective Tissue Diseases
Autoimmune Diseases
Immune System Diseases
Periodontal Diseases
Mouth Diseases
Stomatognathic Diseases