Ultrasound to Evaluate the Quadriceps Muscle Wasting (ECHOSCAN)
|ClinicalTrials.gov Identifier: NCT02562495|
Recruitment Status : Completed
First Posted : September 29, 2015
Last Update Posted : September 6, 2017
Intensive care unit acquired muscle weakness (ICUAW) is a common disease. After 7 days of mechanical ventilation, a quarter of patients develop an ICUAW responsible of a 15-20% of muscle loss. This is a serious pathology associated with high morbidity and mortality.
Clinical diagnosis of ICUAW is difficult and need a patient awoken. CT scan and Magnetic Resonance Imaging (MRI) are considered as "gold standards" to quantify and monitor changes in muscle mass. But these tools are not adapted to ICU patients.
Ultrasound (US) is an easy access tool at the bedside to assess muscle mass and does not expose the patient to additional radiation.
The objective of this study is to evaluate the correlation between US and CT scan to measure quadriceps muscle thickness of ICU patients.
|Condition or disease||Intervention/treatment||Phase|
|Severe Cerebral Pathology||Device: CT Scan and ultrasonography||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||42 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Interest of the Ultrasound to Evaluate the Quadriceps Muscle Wasting in Critical Ill Patients.|
|Actual Study Start Date :||January 21, 2016|
|Actual Primary Completion Date :||August 31, 2017|
|Actual Study Completion Date :||August 31, 2017|
Experimental: CT scan and Ultrasonography
Up to three measurements (CT scan and Ultrasonography), will be made concurrently between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) .
Device: CT Scan and ultrasonography
Up to three measurements (CT scan and Ultrasonography) of the thickness of quadriceps, will be made concurrently .
- Concordance of the measurement of the quadriceps thickness by ultrasound and by CT scan [ Time Frame: Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) ]Concordance of each of the three measurements of the thickness of quadriceps realised concurrently by CT scan and Ultrasonography (composite measure)
- kinetic of the thickness of quadriceps [ Time Frame: Between the day of admission (D1) in intensive care unit and the tenth day ( D10 ) ]Evolution of he thickness of quadriceps measure concurrently by CT scan and Ultrasonography
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02562495
|Saint-etienne, France, 42055|
|Principal Investigator:||Jérôme MOREL, MD||CHU SAINT-ETIENNE|