Cost Effectiveness Analysis of Critical Care in Resource Limited Setting (CEACCLR)
|ClinicalTrials.gov Identifier: NCT02556476|
Recruitment Status : Completed
First Posted : September 22, 2015
Last Update Posted : September 22, 2015
The purpose of this study was to examine the cost effectiveness of critical care in a middle income country with limited resources.
The main study hypothesis was that critical care is cost effective in low resources setting.
|Condition or disease||Intervention/treatment|
|Critical Illness||Procedure: mechanical ventilation Procedure: neuromuscular blockade Procedure: renal replacement therapy Procedure: non-invasive ventilation|
The investigators objective was to calculate the cost effectiveness of treatment of critically ill patients in a medical ICU of a middle income country with limited access to ICU resources.
Methods: Consecutive critically ill medical patients treated in a recently established medical ICU in Sarajevo, Bosnia and Herzegovina, were prospectively recorded and a subsequent cost utility analysis of intensive care in comparison to hospital ward treatment from the perspective of health care system was performed. Incremental cost effectiveness was calculated using estimates of ICU versus non-ICU treatment effectiveness based on a formal systematic review of published studies. Decision analytic modeling was used to compare treatment alternatives. Sensitivity analyses of the key model parameters were performed.
|Study Type :||Observational|
|Actual Enrollment :||148 participants|
|Official Title:||Cost Effectiveness of Intensive Care in a Low Resource Setting: Prospective Cohort of Medical Critically Ill Patients|
|Study Start Date :||June 2011|
|Actual Primary Completion Date :||June 2012|
|Actual Study Completion Date :||June 2013|
The actual cohort of 148 critically ill medical patients that received the treatment in the intensive care unit (ICU). The interventions include interventions that are usually performed within the ICU such as mechanical ventilation, non-invasive ventilation, neuromuscular blockade, renal replacement therapy.
Procedure: mechanical ventilation
ventilator support for the patients presenting with acute respiratory failure
Other Name: ventilator
Procedure: neuromuscular blockade
paralysis of the skeletal muscles in order to optimize mechanical ventilation, especially during ARDS
Other Name: neuromuscular block
Procedure: renal replacement therapy
the procedures used to treat acute kidney injury
Other Name: continuous hemofiltration (CHF) or hemodiafiltration (CHDF)
Procedure: non-invasive ventilation
Procedure used for ventilation support in patients with congestive heart failure, pulmonary edema, COPD and some other conditions.
Other Name: continuous positive airway pressure (CPAP)
- survival [ Time Frame: one year after hospital release ]mortality was recorded one year after hospital discharge and subtracted from the value od 100% in order to get one year survival
- mortality [ Time Frame: 30 days and 60 days after critical illness onset and one year after hospital release ]
- health related quality of life (HRQOL) [ Time Frame: one year after hospital release ]HRQOL was assessed using EQ5D-3L questionnaire
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02556476
|Principal Investigator:||Hajrunisa Cubro, MD||Medical ICU University of Sarajevo Clinical Center, Sarajevo, Bosnia and Herzegovina|
|Study Chair:||Ognjen Gajic, MD, MSc||Division of Pulmonary and Critical Care Mayo Clinic Rochester MN USA|