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Subfoveal Choroidal Thickness in Thai Population

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ClinicalTrials.gov Identifier: NCT02551601
Recruitment Status : Terminated (No new participants)
First Posted : September 16, 2015
Last Update Posted : August 14, 2019
Sponsor:
Information provided by (Responsible Party):
Yosanan Yospaiboon, Khon Kaen University

Brief Summary:
The purpose of this study was to determine the subfoveal choroidal thickness in normal Thai eyes and study the associations with gender, age, refractive error and axial length using spectral-domain optical coherence tomography with enhanced depth imaging technique.

Condition or disease Intervention/treatment
Healthy Other: measure subfoveal choroidal thickness

Detailed Description:
Alteration of choroidal blood supply causes changes in choroidal thickness and results in choroidal abnormalities. These are usually associated with retinal diseases and leading to severe visual dysfunction. Choroidal thickness is therefore helpful in diagnosis and treatment for many chorioretinal conditions. With the advent of spectral domain optical coherence tomography and enhanced depth imaging technique, choroidal thickness has been investigated widely in normal eyes and various chorioretinal diseases including central serous chorioretinopathy (CSC), age-related macular degeneration (AMD), highly myopia and Vogt Koyanagi-Harada disease. Similar to retinal thickness, a normal baseline choroidal thickness might be used for interpretation. This value might be affected by several variables including age, gender and ethnicity. Although there were previous studies on subfoveal choroidal thickness in normal eyes from many countries, there has been no such study in Thailand. The purpose of this study was to determine the subfoveal choroidal thickness in normal Thai eyes and study the associations with gender, age, refractive error and axial length using SD-OCT and EDI technique.

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Study Type : Observational
Actual Enrollment : 150 participants
Observational Model: Case-Only
Time Perspective: Prospective
Official Title: Subfoveal Choroidal Thickness in Thai Population
Actual Study Start Date : August 2015
Actual Primary Completion Date : August 2018
Actual Study Completion Date : August 2018

Group/Cohort Intervention/treatment
Healthy volunteers
to measure the subfoveal choroidal thickness in healthy volunteers
Other: measure subfoveal choroidal thickness
measure subfoveal choroidal thickness using optical coherence tomography




Primary Outcome Measures :
  1. subfoveal choroidal thickness [ Time Frame: up to 4 months ]
    Thickness of choroid at the foveal area



Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Non-Probability Sample
Study Population
Healthy volunteers, age 18 years or above, no ocular diseases
Criteria

Inclusion Criteria:

  • Age 18 years or above
  • Healthy subjects
  • No ocular diseases
  • Written informed consent form

Exclusion Criteria:

  • patients with systemic diseases that may affect retinal or choroidal thickness including diabetes
  • patients with history of refractive surgeries, intraocular surgeries or retinal laser treatments
  • patients with history of macular, retinal, or optic nerve abnormalities

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02551601


Locations
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Thailand
Eye outpatients department, Srinagarind Hospital, Khon Kaen University
Khon Kaen, Thailand, 40002
Sponsors and Collaborators
Khon Kaen University
Investigators
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Principal Investigator: Yosanan Yospaiboon, MD Department of Ophthalmology, Khon Kaen University
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Responsible Party: Yosanan Yospaiboon, Department of Ophthalmology, Faculty of Medicine, Khon Kaen University, Khon Kaen University
ClinicalTrials.gov Identifier: NCT02551601    
Other Study ID Numbers: HE561056
First Posted: September 16, 2015    Key Record Dates
Last Update Posted: August 14, 2019
Last Verified: August 2019
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No
Keywords provided by Yosanan Yospaiboon, Khon Kaen University:
subfoveal choroidal thickness
optical coherence tomography
enhanced depth imaging