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The Behavioral and Brain Mechanism of IGD

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ClinicalTrials.gov Identifier: NCT02550405
Recruitment Status : Completed
First Posted : September 15, 2015
Last Update Posted : December 13, 2018
Sponsor:
Information provided by (Responsible Party):
jintao, zhang, Beijing Normal University

Brief Summary:
This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.

Condition or disease Intervention/treatment Phase
Internet Gaming Disorder Behavioral: Craving behavioral intervention Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 204 participants
Allocation: Non-Randomized
Intervention Model: Parallel Assignment
Masking: Single (Participant)
Primary Purpose: Treatment
Official Title: The Behavioral and Brain Mechanism of Internet Gaming Disorder
Study Start Date : March 2012
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2015

Arm Intervention/treatment
Experimental: Craving behavioral intervention
The craving behavioral intervention (CBI) was developed based on the framework of craving, combining with behavior intervention (Dong and Potenza, 2014), and conducted among individuals with IGD.
Behavioral: Craving behavioral intervention
The CBI was given once a week for 6 weeks, conducted by four therapists. A pair of therapists was randomly assigned to a CBI+ group. Each session included 5 parts in 2.5-3 hours: warming-up exercise, discussion about the homework from the last session, main structured activity, brief summary, and the homework assignment. There were 6 sessions with each focused on a topic: recognize craving and its relationship with IGD; reduce craving through ameliorating the salience of cues and irrational beliefs, withdrawal symptoms and other negative affects; enhance self-monitoring and control for craving through time management training; relieve fulfillment of psychological needs through Internet use and attenuate the relation between craving and gaming behaviors through coping skill training
Other Name: CBI

No Intervention: Control
The control group were individuals with Internet gaming disorder who did not receive any intervention but were scanned twice with the similar interval period as experimental group.



Primary Outcome Measures :
  1. Brain resting state functional connectivity as measured by fMRI [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    voxel-wise, ROI-wise, and ICA analyses

  2. Brain activation during a cue-induced craving task as measured by fMRI [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    A paradigm using addictive pictures to induce craving


Secondary Outcome Measures :
  1. Brain activation during the Cups task as measured by fMRI [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    Cups task measuring risky decision-making related to potential gains and losses separately

  2. Brain activation during the mixed gambling task tasks as measured by fMRI [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    The mix gambling task measuring decision-making related to loss aversion

  3. Brain structure as measured by structural MRI [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    comparing gray matter and white matter differences between individuals with IGD and healthy controls.

  4. IGD severity measured by Chen Internet addiction scale [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    a 26-item 4-point Likert scale

  5. Craving as measured by brief questionnaire of Internet (gaming) craving [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    a 8-item 7-point Likert scale

  6. Impulsivity as measured by Barratt impulsive scale (BIS-II) [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    a 30-item 4-point Likert scale

  7. weekly online (gaming) time [ Time Frame: Detecting changes between two different time points (baseline and 6 weeks) ]
    self-report,in hours



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Ages Eligible for Study:   18 Years to 30 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Inclusion criteria for IGDs were:

    1. a score of 67 or higher on the CIAS;
    2. engagement in Internet gaming for over 14 hours per week for a minimum of one year; and
    3. reporting of Internet gaming as their primary online activity;
  • Inclusion criteria for HCs were:

    1. a score < 60 on the CIAS;
    2. never having spent more than 2 hours per week engaged in Internet gaming

Exclusion Criteria:

  • for all participants:

    1. current or history of use of illegal substances and gambling;
    2. current or history of psychiatric or neurological illness; and
    3. current use of psychotropic medications

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02550405


Locations
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China, Beijing
State Key Laboratory of Cognitive Neuroscience and Learning
Beijing, Beijing, China, 100875
Sponsors and Collaborators
Beijing Normal University
Investigators
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Study Chair: XiaoYi Fang, PhD Institute of Developmental Psychology, Beijing Normal University
Study Chair: JinTao Zhang, PhD State Key Laboratory of Cognitive Neuroscience and Learning
Principal Investigator: CuiCui Xia, MEd Institute of Developmental Psychology, Beijing Normal University
Principal Investigator: LinYuan Deng, PhD Faculty of Education Beijing Normal University
Principal Investigator: Lu Liu, BS Institute of Developmental Psychology, Beijing Normal University
Principal Investigator: Ben Liu, BSM State Key Laboratory of Cognitive Neuroscience and Learning
Principal Investigator: ShanShan Ma, BS State Key Laboratory of Cognitive Neuroscience and Learning
Principal Investigator: YuanWei Yao, BS State Key Laboratory of Cognitive Neuroscience and Learning
Principal Investigator: Qinxue Liu, PhD School of Psychology Central China Normal University
Principal Investigator: Nan Zhou, MEd Institute of Developmental Psychology, Beijing Normal University
Principal Investigator: ShuMeng Hou, MEd Institute of Developmental Psychology, Beijing Normal University