Exercise in Genetic Cardiovascular Conditions (LIVE-HCM/LQT)
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ClinicalTrials.gov Identifier: NCT02549664 |
Recruitment Status :
Recruiting
First Posted : September 15, 2015
Last Update Posted : October 18, 2017
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Condition or disease |
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Hypertrophic Cardiomyopathy Long QT Syndrome |
Study Type : | Observational [Patient Registry] |
Estimated Enrollment : | 4286 participants |
Observational Model: | Cohort |
Time Perspective: | Prospective |
Target Follow-Up Duration: | 3 Years |
Official Title: | Exercise in Genetic Cardiovascular Conditions (Lifestyle and Exercise in Hypertrophic Cardiomyopathy "LIVE-HCM"/Lifestyle and Exercise in the Long QT Syndrome "LIVE-LQTS" |
Study Start Date : | May 2015 |
Estimated Primary Completion Date : | May 2018 |
Estimated Study Completion Date : | May 2020 |

Group/Cohort |
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LQT/HCM sedentary patients
LQT/HCM sedentary lifestyle
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LQT/HCM moderate/vigorous exercise
LQT/HCM participate in moderate or vigorous exercise
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- Composite risk of death, cardiac arrest, ventricular arrhythmias, or syncope in individuals with HCM or LQTS who are participating in moderate or vigorous exercise and in sedentary individuals. [ Time Frame: Five years ]
- Emotional Quality of Life assessed using Pediatric Cardiac Quality of Life Inventory (Pcqli) [ Time Frame: Five years ]Will assess using Pediatric Cardiac Quality of Life Inventory (Pcqli)
- Physical Quality of Life assessed using Pediatric Quality of Life Inventory (PedsQL) [ Time Frame: Five Years ]Will assess using Pediatric Quality of Life Inventory (PedsQL)
- Physical Quality of Life assessed using Health Status Questionnaire (SF36) Quality of Life for Adults [ Time Frame: Five Years ]Will assess using Health Status Questionnaire (SF36) Quality of Life for Adults

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Ages Eligible for Study: | 8 Years to 60 Years (Child, Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Inclusion Criteria:
- Individuals with Hypertrophic Cardiomyopathy or Long QT Syndrome
Exclusion Criteria:
- Individuals with Hypertrophic Cardiomyopathy with systolic or diastolic heart failure which precludes vigorous exercise will not be enrolled (NYHA III/IV)

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02549664
Contact: Theresa Donovan, BS | 866-207-9813 | theresa.donovan@yale.edu | |
Contact: Cheryl Barth, BS | 203-737-1079 | cheryl.barth@yale.edu |

Principal Investigator: | Rachel Lampert, MD | Yale University |
Additional Information:


Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
Responsible Party: | Yale University |
ClinicalTrials.gov Identifier: | NCT02549664 History of Changes |
Other Study ID Numbers: |
1411014982 1R01HL125918-01 ( U.S. NIH Grant/Contract ) |
First Posted: | September 15, 2015 Key Record Dates |
Last Update Posted: | October 18, 2017 |
Last Verified: | December 2016 |
Keywords provided by Yale University:
Hypertrophic Cardiomyopathy (HCM) Long QT Syndrome (LQTS) |
Additional relevant MeSH terms:
Syndrome Cardiomyopathies Hypertrophy Cardiomyopathy, Hypertrophic Long QT Syndrome Disease Pathologic Processes Heart Diseases Cardiovascular Diseases |
Pathological Conditions, Anatomical Aortic Stenosis, Subvalvular Aortic Valve Stenosis Heart Valve Diseases Arrhythmias, Cardiac Heart Defects, Congenital Cardiovascular Abnormalities Congenital Abnormalities |