Proteinuria During Acute Pyelonephritis In Pregnancy
|ClinicalTrials.gov Identifier: NCT02536638|
Recruitment Status : Unknown
Verified August 2015 by Kenneth Chan, MD, MemorialCare Health System.
Recruitment status was: Recruiting
First Posted : September 1, 2015
Last Update Posted : September 1, 2015
|Condition or disease||Intervention/treatment|
|Proteinuria||Other: Exposure to pyelonephritis|
Preeclampsia is a pregnancy-unique disorder that is cured only with delivery of the baby, even if the pregnancy is premature. Defined by both blood pressure and proteinuria criteria, diagnosis is often obscured by renal processes like systemic lupus erythematosus or nephrotic syndrome that increase urinary protein spillage. Proteinuria is defined as a total protein urinary excretion exceeding 300 mg in a 24-hour urine collection in pregnancy. This is suggested to be double the protein excretion in the non-pregnancy population at 150 mg/day. A mean 24-hour urine protein excretion of 204.3 mg (± 92.5) was found in the non-hypertensive pregnant population.
Physiological changes in pregnancy predispose patients to urinary tract infections; ureteral compression by the gravid uterus, progesterone-mediated slowing of ureteral peristalsis and decreased bladder tone, and mechanical compression of the bladder contribute to impaired clearance of bacteria from the urinary tract. Indeed, acute cystitis complicates 2-4% of all pregnancies. While it has been said that urinary tract infections increase proteinuria, it is unknown how much protein spillage should be expected in the general or the pregnant populations. Hence a patient with pyelonephritis may obscure the diagnosis of preeclampsia if she spills urinary protein from her infection.
The purpose of this study is to compare the mean of 24-hour urine protein in pregnant patients with and without acute pyelonephritis.
The importance of this study will be to determine if urine protein excretion is in fact increased in the setting of pyelonephritis. This will allow for reliable evaluation of urine protein during the work up for preeclampsia in those women also found having a kidney infection.
|Study Type :||Observational|
|Estimated Enrollment :||48 participants|
|Observational Model:||Case Control|
|Official Title:||Quantitating Proteinuria During Acute Pyelonephritis In Pregnancy|
|Study Start Date :||July 2015|
|Estimated Primary Completion Date :||February 2017|
patients with pyelonephritis
Other: Exposure to pyelonephritis
Pyelonephritis group are patients with exposure to pyelonephritis Without pyelonephritis group are patients without pyelonephritis
Without pyelonephritis Group
patients without pyelonephritis
- 24-hour urine protein [ Time Frame: 7 days ]urine protein will be measured upon patient enrollment to the study (i.e. during the study enrollment hospitalization)
Biospecimen Retention: Samples With DNA
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02536638
|Contact: Cindy T Chau, MDfirstname.lastname@example.org|
|Contact: Kenneth Chan, MDemail@example.com|
|United States, California|
|Miller Children's and Women's Hospital at Long Beach Memorial Medical Center||Recruiting|
|Long Beach, California, United States, 90806|
|Contact: Cindy T Chau, MD 562-997-8510 firstname.lastname@example.org|
|Contact: Kenneth Chan, MD 5629978510 email@example.com|
|Principal Investigator:||Kenneth Chan, MD||Maternal Fetal Medicine|