Effect of Dexmedetomidine on Heart-rate Corrected QT(QTc) Interval Prolongation During Robotic-assisted Laparoscopic Radical Prostatectomy -Randomized Blind Clinical Trial-
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|ClinicalTrials.gov Identifier: NCT02536014|
Recruitment Status : Completed
First Posted : August 31, 2015
Last Update Posted : January 29, 2016
Sympathetic activity could be increased during robot-assisted laparoscopic radical prostatectomy, which is performed in a steep trendelenburg position under CO2 pneumoperitoneum.
Stimulation of the sympathetic nervous system prolongs the QT interval and can increases the susceptibility to life threatening cardiac arrhythmias.
Dexmedetomidine has sympatholytic effects and potential antiarrhythmic properties. Perioperative administration of dexmedetomidine is a potential preventive and treatment strategy for tachyarrhythmia. Thus the investigators decided to evaluate the effect of dexmedetomidine on heart-rate corrected QT interval during robot-assisted laparoscopic radical prostatectomy. Furthermore, the investigators evaluated the Tp-e, Tp-e/QT ratio and Tp-e/QTc ratio as well.
|Condition or disease||Intervention/treatment||Phase|
|Prostate Cancer Robotic Surgery||Drug: Dexmedetomidine Drug: Saline||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||50 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Study Start Date :||August 2015|
|Actual Primary Completion Date :||January 2016|
|Actual Study Completion Date :||January 2016|
Dexmedetomidine infusion (0.3㎍/kg/hr) from anesthetic induction to the end of pneumoperitoneum
|Active Comparator: Saline||
Saline infusion during the same time period
- Dexmedetomidine on heart-rate corrected QT(QTc) interval [ Time Frame: From pre-induciton until 60 min after the end of pneumoperitoneum ]QTc intervals (msec) are recorded from pre-induction until 60 min after the end of pneumoperitoneum
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02536014
|Korea, Republic of|
|Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institue, Yonsei Universiy College of Medicine|
|Seoul, Korea, Republic of, 03722|