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Neural Correlates of Stress Hormones (Cort-fMRI)

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02523664
Recruitment Status : Completed
First Posted : August 14, 2015
Last Update Posted : February 5, 2019
Information provided by (Responsible Party):
Katja Wingenfeld, Charite University, Berlin, Germany

Brief Summary:
To investigate which neuronal correlates underlie cortisol-induced enhancement of memory retrieval in PTSD and BPD.

Condition or disease Intervention/treatment Phase
Borderline Personality Disorder PTSD Drug: Hydrocortisone Drug: Placebo Not Applicable

Detailed Description:

The investigators have recently shown that hydrocortisone enhances rather than impairs memory retrieval in patients with posttraumatic stress disorder (PTSD) and borderline personality disorder (BPD). In contrast, in healthy participants memory retrieval was impaired after hydrocortisone compared to placebo.

The proposed studies aim to further investigate these findings and to understand the underlying neuronal correlates. Thus, the mechanisms of enhanced memory retrieval after hydrocortisone in patients with BPD and PTSD will be investigated by fMRI.

In a placebo-controlled study, the effects of 10mg hydrocortisone on brain activity, in particular the hippocampus, will be investigated in patients with PTSD and BPD and will be compared with those in healthy control participants. During the fMRI session, a declarative memory task (retrieval of a previous learned word list) and an autobiographical memory test will be performed. Effects of hydrocortisone on resting state brain activity and the neuronal correlates of memory retrieval will be analysed.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 78 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Official Title: Why Does Cortisol Enhance Memory Retrieval in Patients With Borderline Personality Disorder and Posttraumatic Stress Disorder? Investigating the Neuronal Correlates of Cortisol Administration and the Effects of Stress Exposure
Study Start Date : January 2014
Actual Primary Completion Date : December 2018
Actual Study Completion Date : December 2018

Arm Intervention/treatment
Active Comparator: Hydrocortisone
10 mg hydrocortisone orally
Drug: Hydrocortisone
effects of hydrocortisone on memory while fMRI

Placebo Comparator: Placebo
placebo orally
Drug: Placebo

Primary Outcome Measures :
  1. brain activation after hydrocortisone [ Time Frame: 20 min ]

Secondary Outcome Measures :
  1. memory retrieval after hydrocortisone [ Time Frame: 10 minutes ]
    Retrieval of a previous learned word list

  2. memory retrieval after hydrocortisone [ Time Frame: 20 minutes ]
    autobiographic memory retrieval

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 40 Years   (Adult)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of Borderline Personality Disorder
  • Clinical diagnosis of PTSD
  • females without psychiatric disorders as control group
  • right handed

Exclusion Criteria:

  • fMRI exclusion criteria e.g. metal implants, pregnancy, left-handedness, and claustrophobia.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02523664

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Charite University
Berlin, Germany
Sponsors and Collaborators
Charite University, Berlin, Germany

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Responsible Party: Katja Wingenfeld, Prof. Dr., Charite University, Berlin, Germany Identifier: NCT02523664     History of Changes
Other Study ID Numbers: WI-3396-2
First Posted: August 14, 2015    Key Record Dates
Last Update Posted: February 5, 2019
Last Verified: February 2019
Additional relevant MeSH terms:
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Personality Disorders
Borderline Personality Disorder
Mental Disorders
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Hydrocortisone hemisuccinate
Anti-Inflammatory Agents