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A Prospective Household Observational Cohort Study of Influenza, Respiratory Syncytial Virus and Other Respiratory Pathogens Community Burden and Transmission Dynamics in South Africa (PHIRST-SA)

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ClinicalTrials.gov Identifier: NCT02519803
Recruitment Status : Unknown
Verified August 2015 by National Institute for Communicable Diseases, South Africa.
Recruitment status was:  Not yet recruiting
First Posted : August 11, 2015
Last Update Posted : August 11, 2015
Sponsor:
Collaborator:
Perinatal HIV Research Unit of the University of the Witswatersrand
Information provided by (Responsible Party):
National Institute for Communicable Diseases, South Africa

Brief Summary:
Title: A Prospective Household observational cohort study of Influenza, Respiratory Syncytial virus and other respiratory pathogens community burden and Transmission dynamics in South Africa (The PHIRST Study) This study will improve understanding of the community burden of influenza, RSV, pertussis, tuberculosis and pneumococcal infection in South Africa. It will also provide data on the carriage prevalence of meningococcus and diphtheria. The data generated from this study will also provide important information on the transmission dynamics of influenza, RSV, pertussis and pneumococcus in the community allowing to better strategize interventions (including targeted vaccination strategies) and evaluate their potential impact. Moreover, there is an absence of prospective data on tuberculosis infection from high tuberculosis burden countries. The data generated will both inform modelling of transmission, sample size for prevention studies and surveillance assessing the impact of the National Tuberculosis Control Program.

Condition or disease
Infective Organism Causing Respiratory Diseaseand Meningitis

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Study Type : Observational
Estimated Enrollment : 4500 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Prospective Household Observational Cohort Study of Influenza, Respiratory Syncytial Virus and Other Respiratory Pathogens Community Burden and Transmission Dynamics in South Africa
Study Start Date : January 2016
Estimated Primary Completion Date : December 2018
Estimated Study Completion Date : December 2018

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Flu Flu Shot




Primary Outcome Measures :
  1. Secondary attack rate of influenza and RSV [ Time Frame: one year ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
two community based sites, one site is rural and the other is an urban setting. all household in these 2 districts are eligible. Household will be randomly selected on a cluster sampling method
Criteria

Inclusion Criteria:

  • Household members of selected household fitting definition of member of household

Exclusion Criteria:

  • unwilling to give informed consent does not meet criteria for permanent household member
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Responsible Party: National Institute for Communicable Diseases, South Africa
ClinicalTrials.gov Identifier: NCT02519803    
Other Study ID Numbers: PHIRST-SA
First Posted: August 11, 2015    Key Record Dates
Last Update Posted: August 11, 2015
Last Verified: August 2015
Additional relevant MeSH terms:
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Meningitis
Central Nervous System Diseases
Nervous System Diseases