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Epidemiology of Acute Self-poisoning in Emergency Services in France (EpiTox)

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ClinicalTrials.gov Identifier: NCT02518386
Recruitment Status : Completed
First Posted : August 7, 2015
Last Update Posted : April 17, 2019
Sponsor:
Collaborator:
French Society of Emergency Medicine
Information provided by (Responsible Party):
University Hospital, Grenoble

Brief Summary:

Acute self poisoning is a leading cause of suicide attempts and leads to frequent emergency department visits. However, the exact epidemiology of acute self poisoning is not known. The description of the clinical pathway and the characteristics of patients with acute self poisoning could lead to an improvement in emergency care.

The Investigators will conduct a 48h observational study in emergency services in France. Investigators primary objective is to gathered epidemiological clinical and treatment data during emergency dispatch, prehospital care and inhospital emergency care.


Condition or disease Intervention/treatment
Suicide Attempts Other: No intervention

Detailed Description:

Acute self poisoned patients will be prospectively and anonymously recruited by emergency physicians in charge during two days. Acute self poisoning is define as follow: intentional medicine intake in the 24h hours before emergency department admission.

Epidemiological, clinical, toxicological and treatment data will be gathered. Outcome of patient will be prospectively assessed at 30days.

All data will be transmitted to the principal investigators. Then, 20% of the data will be monitored by an independent committee.

Exhaustivity will be retrospectively assessed by the number of inclusions in 10 emergency centers divided by the total number of possible inclusions in these centers.

Finally, an independent statistician will be in charge of the analysis.

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Study Type : Observational [Patient Registry]
Actual Enrollment : 700 participants
Observational Model: Cohort
Time Perspective: Prospective
Target Follow-Up Duration: 1 Month
Official Title: Evaluation of the Epidemiology and the Take Load of Voluntary Drug Intoxications by the Emergency Structures in France
Actual Study Start Date : March 2015
Actual Primary Completion Date : April 2015
Actual Study Completion Date : June 2016

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Poisoning Suicide


Intervention Details:
  • Other: No intervention
    No intervention is planned


Primary Outcome Measures :
  1. Percentage of each drug class [ Time Frame: 48h ]

Secondary Outcome Measures :
  1. odds ratio of drug classes according to sexe and age [ Time Frame: 48h ]
  2. number of participants with poisoning incident [ Time Frame: 48h ]
  3. prehospital and inhospital mortality [ Time Frame: 30 days ]
  4. percentage of each antidotal treatment [ Time Frame: 48h ]
  5. mobile intensive care unit (percentage) dispatch [ Time Frame: 30 days ]
  6. Age according to drug classes ingestion [ Time Frame: 48h ]
    Median age compared according drug classes ingestion

  7. Gender according to drug classes ingestion [ Time Frame: 48h ]
    Pourcentage of gender compared according drug classes ingestion

  8. Time (median) of admission according to drug classes ingestion [ Time Frame: 48h ]
  9. Time (median) of admission according unit of admission [ Time Frame: 48h ]
  10. Mortality according to drug class ingestion [ Time Frame: 30 days ]
  11. ICU admission according to drug class ingestion [ Time Frame: 30 days ]
  12. icu admission (percentage) [ Time Frame: 48h ]
  13. percentage of errors according to the Grenoble clinical decision rule [ Time Frame: 30 days ]
  14. multivariate analysis to describe factors associated with ICU admission [ Time Frame: 30 days ]
  15. multivariate analysis to describe factors associated with mobile intensive care unit dispatch [ Time Frame: 30 days ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Patients dispatched of admitted for acute self poisoning in emergency medical services and/or emergency departments
Criteria

Inclusion Criteria:

  • acute self poisoning defined as the intentional intake (oral, nasal, injection etc.) of medicines during the 24h before first medical contact

Exclusion Criteria:

  • cardiac arrest at first medical contact (dispatch or physician)
  • acute self poisoning without any medication intake
  • non intentional poisoning

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02518386


Sponsors and Collaborators
University Hospital, Grenoble
French Society of Emergency Medicine
Investigators
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Principal Investigator: Maxime Maignan, MD MSc Emergency department, CHU Grenoble
Additional Information:

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Responsible Party: University Hospital, Grenoble
ClinicalTrials.gov Identifier: NCT02518386    
Other Study ID Numbers: EpiTox
First Posted: August 7, 2015    Key Record Dates
Last Update Posted: April 17, 2019
Last Verified: April 2019
Keywords provided by University Hospital, Grenoble:
emergency department
epidemiology
prehospital care
dispatch
acute self poisoning
Additional relevant MeSH terms:
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Emergencies
Suicide
Suicide, Attempted
Disease Attributes
Pathologic Processes
Self-Injurious Behavior
Behavioral Symptoms