Natural History of Multiple Sclerosis and Its Mimickers
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|ClinicalTrials.gov Identifier: NCT02504840|
Recruitment Status : Recruiting
First Posted : July 22, 2015
Last Update Posted : February 14, 2018
- Magnetic resonance imaging (MRI) has been used for decades to help diagnose and monitor neurological disorders like multiple sclerosis (MS). Researchers want to improve how MRI pictures are taken. They also want to learn more about using newer MRIs with stronger magnets to get better pictures than standard MRIs provide.
- To collect data that will help researchers better understand MS and related diseases.
- Adults 18 and older with MS or MRI findings that appear similar to MS, or with other neurological diseases that may look or act like MS.
- Healthy adult volunteers.
- Participants will be screened with a review of their medical records.
- Participants will have a baseline visit. It will include a physical exam, medical history, and neurological exam. They may have blood tests.
- The study will last indefinitely.
- Participants may have MRIs. Some MRIs may include a contrast dye. For this, a needle will be used to guide a thin plastic tube into an arm vein.
- Participants may have up to 2 lumbar punctures per year. Skin will be numbed and a needle inserted between back bones will remove fluid.
- Participants may give saliva samples and have an eye exam.
- Participants may have evoked potential tests. These measure how the nervous system responds to different types of stimulation. Participants may sit in front of a TV and watch pictures on the screen. Or they may wear earphones that make a clicking noise or static. Or they may get a small electrical shock that may tingle and cause a hand or foot twitch.
- Participants may have tests of strength, spasticity, sensations, balance, and/or walking.
|Condition or disease|
|Neurologic Disorders Healthy Volunteers Multiple Sclerosis|
Show Detailed Description
|Study Type :||Observational|
|Estimated Enrollment :||1300 participants|
|Official Title:||Thematic Studies of Multiple Sclerosis and Related Diseases|
|Study Start Date :||July 21, 2015|
|Estimated Primary Completion Date :||February 26, 2041|
|Estimated Study Completion Date :||August 26, 2041|
- Association between MRI findings and clinical status [ Time Frame: 25 Years ]
- Focal brain lesions: presence, extent, imaging characteristics, distribution, and changes over time [ Time Frame: 25 Years ]
- Brain volume, brain-substructure, and spinal-cord volumes [ Time Frame: 25 Years ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02504840
|Contact: Joan M Ohayon, C.R.N.P.||(301) firstname.lastname@example.org|
|United States, Maryland|
|National Institutes of Health Clinical Center, 9000 Rockville Pike||Recruiting|
|Bethesda, Maryland, United States, 20892|
|Contact: For more information at the NIH Clinical Center contact Patient Recruitment and Public Liaison Office (PRPL) 800-411-1222 ext TTY8664111010 email@example.com|
|Principal Investigator:||Daniel S Reich, M.D.||National Institutes of Health Clinical Center (CC)|