Short-term Effects of Humidification Devices on Respiratory Pattern and Work of Breathing During Invasive Ventilation
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|ClinicalTrials.gov Identifier: NCT02499796|
Recruitment Status : Completed
First Posted : July 16, 2015
Last Update Posted : February 14, 2018
|Condition or disease||Intervention/treatment||Phase|
|Chronic Respiratory Failure||Device: Hygrovent Gold Device: Heated and moisture exchanger (HME) Device: Heated humidifier (HH)||Not Applicable|
Three humidifying devices are commonly and indifferently used during mechanical ventilation, but their impact on respiratory mechanics and, eventually, mechanical ventilation efficacy, particularly in patients highly dependent from mechanical ventilation, are not superimposable.
It has already been described that heated and moisture exchangers (HME), increasing dead space, can negatively affect ventilatory function and gas exchange, in comparison to heated humidifiers (HH).
The Hygrovent Gold, mainly because of its position between the tracheostomy and the Y-piece of the ventilatory circuit and its structure, may lead to analogous or even worse effects, determining and increase in inspiratory resistances and dead space and consequently an increase in the work of breathing.
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||15 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Short-term Effects of Humidification Devices on Respiratory Pattern and Work of Breathing During Invasive Ventilation|
|Study Start Date :||April 2015|
|Actual Primary Completion Date :||September 2015|
|Actual Study Completion Date :||September 2015|
Experimental: Single Arm
Every patient receives 20 minutes of invasive mechanical ventilation with each of the three humidification systems in random sequence:
Device: Hygrovent Gold
Device: Heated and moisture exchanger (HME)
Device: Heated humidifier (HH)
- Change in muscle pressure-time product (PTPoes) [ Time Frame: Baseline and 60 minutes ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02499796
|Fondazione Salvatore Maugeri|
|Pavia, Italy, 27100|
|Study Chair:||Piero Ceriana, MD||Fondazione Salvatore Maugeri|