Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis (Peridialysis)

• ClinicalTrials.gov Identifier: NCT02488200
• Recruitment Status: Unknown
• First Posted: July 2, 2015
• Last Update Posted: February 26, 2018
• Sponsor: Herlev Hospital
• Collaborators: Odense University Hospital; Aarhus University Hospital Skejby; Zealand University Hospital; Holbaek Sygehus; Central Jutland Regional Hospital; Sonderborg Hospital; Skovde Hospital; Karolinska University Hospital; Lund University Hospital; Turku University Hospital; Pauls Stradins Clinical University Hospital; Tartu University Hospital; The Hospital of Vestfold; St. Olavs Hospital; Oslo University Hospital
• Information provided by (Responsible Party): James heaf, Herlev Hospital

Study Description

Brief Summary:

The present study plans to delineate the clinical, biochemical, sociological and psychological factors. involved in dialysis preparation, and their impact on dialysis initiation (DI), modality choice and prognosis. In particular the following questions are to be answered.

1. What factors influence unplanned DI?
2. What factors influence choice of dialysis modality?
3. What factors influence choice of dialysis access?
4. Why do physicians start dialysis?
5. What factors in the predialytic period and its immediate aftermath (the "peridialytic" period) influence prognosis?

Condition or disease	Intervention/treatment
End Stage Renal Disease	Other: No intervention

Detailed Description:

Patients All patients starting active end stage renal disease (ESRD) treatment at the participating centres and their satellite centres.

No. Patients: 1000.

1. Patients who have received their recent predialysis care at another centre can be included if the previous centre's notes are available, otherwise not.
2. Patients receiving a preemptive transplant are included, even if the transplant is performed at another centre. A patient questionnaire is not required for these patients.
3. Africans are excluded (inaccurate estimated glomerular filtration rate (eGFR) calculation) Each patient is allocated a local identity number (1,2,3….). The local author keeps a registry of the true patient identity of each identity number for follow-up purposes. This registry is not to be used in any communication outside the centre.

Comment: Most patients have known chronic uremia at dialysis start. In a few cases, it is unknown whether the uremia is acute or chronic. There are two main groups:

1. Acute uremia of unknown origin. Doctors should fill the questionnaire in Table 2, which can be discarded if the patient recovers renal function within three months.
2. Acute kidney injury (AKI). Most of these patients will recover within three months, so the questionnaire can wait, and be filled in retrospectively for the few remaining patients.

Methods

1. Each participating centre fills a Centre Questionnaire, see Table 1.
2. All prescribing doctors fill in a voluntary Physician Questionnaire, see Table 4.
3. The doctor prescribing the first dialysis fills in a Motivation Questionnaire, see Table 2.

4. The local coordinator fills in a Patient Notes Review

   1. Birthday
   2. Sex
   3. Height and weight
   4. Renal diagnosis
   5. Comorbidity
   6. Date and creatinine at referral to nephrology dept.
   7. Date and creatinine 6 months before dialysis start
   8. Date and creatinine 3 months before dialysis start
   9. Date and creatinine at start of dialysis information/choice
   10. Date and creatinine at access prescription. Date and creatinine at access creation. If there are several attempts at access creation, the last attempt is registered. For unplanned dialysis start, this is often the same date as dialysis start.
   11. Date of dialysis start
   12. Following values before first dialysis: B-hemoglobin, p- creatinine, urea, potassium, calcium, phosphate, bicarbonate, albumin
   13. Initial dialysis modality (centre hemodialysis (HD)/Home HD/continuous ambulatory peritoneal dialysis (CAPD)/ automated peritoneal dialysis (APD))
   14. Type of start (Planned/unplanned)
   15. Reason for unplanned start (primary and (if appropriate) secondary).
   16. For hemodialysis patient (HD) patients, initial access (areteriovenous fisula (AVF)/arteriovenous graft (AVG) /tunneled central venous catheter (CVC)/temporary CVC)
   17. Modality after 3 months (Center HD/Home HD/CAPD/APD/regained function/Transplanted/Dead)
   18. Is the patient alive after 3 months Yes/No. If "No" Date of death.
   19. Is the patient alive after 6 months Yes/No.
   20. If "No" Date of death.Is the patient alive after 12 months Yes/No. If "No" Date of death.
   21. Was the patient transplanted after inclusion? If so, when?

Responsibilities National coordinators are responsible for translation of protocol to local language, and compliance with any necessary national regulatory requirements (data protection agency, ethical committee?) Local representatives: local coordination and follow-up. Patient notes review. Additional secretarial assistance, paid or unpaid, is permitted.

Definitions

ESRD

A patient has ESRD if any of the following:

1. He receives a transplant
2. The doctor "believes" that he has ESRD at first dialysis
3. He has received >90 days dialysis
4. If the doctor is in doubt whether the patient has acute or chronic renal failure, the patient is registered as soon as there is no doubt that the patient has ESRD For 3 & 4, registration is performed retrospectively from the first dialysis day.

Planned dialysis

The patient's first dialysis is planned if:

1. His first hemodialysis uses an AV fistula
2. His first hemodialysis uses a permanent catheter as the patient's permanent access
3. His first peritoneal dialysis is >6 days after catheter placement.

The patient's first dialysis is unplanned if:

1. His first hemodialysis uses a temporary catheter
2. His first hemodialysis uses a permanent catheter as the patient's temporary access (i.e. a later AV fistula is planned.
3. His first peritoneal dialysis is <7 days after catheter placement.

Renal Diagnoses

1. Shrunken Kidneys of unknown cause
2. Glomerulonephritis
3. Chronic interstitial nephropathy, chronic pyelonephritis and postrenal uremia
4. Polycystic kidney disease
5. Hypertensive/atherosclerotic renal disease
6. Diabetic Nephropathy
7. Other

Causes of unplanned dialysis

1. Late referral
2. Acute uremia
3. Acute progression of chronic uremia
4. Doubt about reversibility
5. Clinical indication despite acceptable biochemistry
6. Fistula problems
7. Delayed planning (Controversial. I recommend dialysis planning at the latest when eGFR <15 ml/minute. Please use your own definition).
8. Patient non-compliance
9. Patient refused dialysis, but later changed his/her mind

Causes of PD modality

1. Patient choice
2. Cardiac insufficiency
3. HD not possible

Causes of HD Modality

1. Patient Choice
2. Physically incapable of peritoneal dialysis (PD)
3. Mentally incapable of PD
4. Abdominal problems
5. Wish for Home HD
6. PD not considered

Table 1 Center Questionnaire

1. Author:
2. Centre Name:
3. Centre type: University/Non-academic
4. Approximate population covered:
5. No. new ESRD patients/year

6. How many of these

   1. Preemptive transplant (%)?
   2. PD (%)?
   3. HD (%)?

7. What is the

   1. PD prevalence (no. patients)?
   2. HD prevalence?
8. How many nephrology specialists?

9. Does the department have an official policy concerning preferred initial modality:

   1. No
   2. PD first
   3. Home HD first
   4. Other (what?)
10. Does the department have an official policy concerning when pretransplant investigations should be initiated? If so what? If not, is there unofficial consensus? What?
11. Does the department have an official policy concerning when dialysis modality choice is made? If so what? If not, is there unofficial consensus? What?
12. Does the department have an official policy concerning when AV fistulae/grafts are prescribed? If so what? If not, is there unofficial consensus? What?
13. Does the department have an official policy concerning when peritoneal dialysis catheters are prescribed? If so what? If not, is there unofficial consensus? What?
14. Does the department have an official policy concerning when chronic dialysis is prescribed? If so what? If not, is there unofficial consensus? What?

Table 2. Motivation Questionnaire

You have just prescribed this patient's first dialysis. If you do not believe that the patient's dialysis requirement is chronic, you do not have to fill in this form Put a "1" besides the primary reason for starting dialysis today. Put a "2" besides a (possible) secondary reason for starting dialysis today. Put a "X" besides any other reasons that have been important in influencing your decision to prescribe dialysis today.

Taste disturbances Pulmonary stasis Social (what?) Dyspnea Practical (what?) (e.g. catheter protection) Hypertension Pericarditis Oedema Biochemical Cardiac symptoms High Plasma-Creatinine Fatigue High Urea Anorexia Low glomerular filtration rate (GFR) Nausea/vomiting High Potassium Cachexia/weight loss Acidosis Itching Low calcium Insomnia High Calcium Depression High Phosphate Diarrhea Falling GFR Other (what?)

Table 4. Physician Questionnaire What is your age? What is your sex? Are you a nephrology specialist? How many years have you been a doctor? How many years have you been a nephrology specialist?

Study Design

• Study Type: Observational [Patient Registry]
• Estimated Enrollment: 1400 participants
• Observational Model: Cohort
• Time Perspective: Prospective
• Target Follow-Up Duration: 1 Year
• Official Title: Peridialysis Project: The Influence of Predialysis Factors on the Initial Course of Dialysis
• Study Start Date: January 2015
• Estimated Primary Completion Date: January 2019
• Estimated Study Completion Date: January 2020

Groups and Cohorts

Intervention Details:

• Other: No intervention
  No intervention

Outcome Measures

Primary Outcome Measures :

1. Proportion of patients who start planned dialysis initiation as defined by the protocol [ Time Frame: 1 year ]

   Planned dialysis

   The patient's first dialysis is planned if:

   1. His first hemodialysis uses an AV fistula
   2. His first hemodialysis uses a permanent catheter as the patient's permanent access
   3. His first peritoneal dialysis is >6 days after catheter placement.

   The patient's first dialysis is unplanned if:

   1. His first hemodialysis uses a temporary catheter
   2. His first hemodialysis uses a permanent catheter as the patient's temporary access (i.e. a later AV fistula is planned.
   3. His first peritoneal dialysis is <7 days after catheter placement.

Secondary Outcome Measures :

1. Death [ Time Frame: 1 year ]
   Time to patient death
2. Choice of dialysis modality [ Time Frame: 1 year ]
   Centre HD, Home HD, CAPD or APD
3. Choice of dialysis access [ Time Frame: 1 year ]
   AVF, AVG, Temporary CVC, Tunneled CVC, or PD catheter

Eligibility Criteria

• Ages Eligible for Study: 1 Month to 95 Years (Child, Adult, Older Adult)
• Sexes Eligible for Study: All
• Accepts Healthy Volunteers: No
• Sampling Method: Non-Probability Sample

Study Population

Patients with Chronic Kidney Disease Stage 5 WHO start dialysis therapy for ESRD

Criteria

Inclusion Criteria:

• All patients starting maintenance dialysis therapies at the participating centers

Exclusion Criteria:

• Africans

Contacts and Locations

Contacts

Contact: James G Heaf, MD DMSc; +4535125361; heaf@dadlnet.dk

Locations

Denmark

Herlev Hospital; Recruiting

Herlev, Denmark, 2730

Contact: James G Heaf, MD DMSc +4535125361 heaf@dadlnet.dk

Sponsors and Collaborators

Herlev Hospital

Odense University Hospital

Aarhus University Hospital Skejby

Zealand University Hospital

Holbaek Sygehus

Central Jutland Regional Hospital

Sonderborg Hospital

Skovde Hospital

Karolinska University Hospital

Lund University Hospital

Turku University Hospital

Pauls Stradins Clinical University Hospital

Tartu University Hospital

The Hospital of Vestfold

St. Olavs Hospital

Oslo University Hospital

Investigators

• Principal Investigator: James G Heaf, MD DMSc; Herlev Hospital

More Information

Additional Information:

• Responsible Party: James heaf, Doctor, Herlev Hospital
• ClinicalTrials.gov Identifier: NCT02488200
• Other Study ID Numbers: CRU ID 15002474
• First Posted: July 2, 2015
• Last Update Posted: February 26, 2018
• Last Verified: February 2018

Individual Participant Data (IPD) Sharing Statement:

• Plan to Share IPD: No

Additional relevant MeSH terms:

Kidney Failure, Chronic; Kidney Diseases; Urologic Diseases; Renal Insufficiency, Chronic; Renal Insufficiency