How Family Coping With Child Cancer Affects Child's Quality of Life?
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|ClinicalTrials.gov Identifier: NCT02470975|
Recruitment Status : Recruiting
First Posted : June 12, 2015
Last Update Posted : April 7, 2020
|Condition or disease|
Researchers and clinicians alike have been calling for family-oriented and longitudinal research on child cancer (CC). The reason for this is threefold. First, parents are the most influential context on child development. Second, CC can be considered a "we-family disease", that is, a stressor that affects the patient, their parents and the interaction within all family members and subsystems, since they are an interdependent unit. Third, the higher survivals rates and increased chronicity of CC demand an ongoing adaptation from the whole family to the illness-related stress. As such, several studies have found associations between family and child variables during and after cancer treatment, and few studies suggest a causal relationship of family functioning on child adjustment and quality of life (QoL). Nevertheless, (1) which family dimensions related with the process of stress, appraisal and coping with CC, (2) how changes and (3) divergences within those dimensions predict child QoL over time, remain answered. Research on stress and coping in couples has identified two crucial dimensions for better relational and health outcomes that have the potential to provide those answers. "We-Appraisals", which is the process how individuals tend to evaluate what happens to them as a couple, i.e., in a more relational-oriented way ("we" problem) or in a more individual way ("I/you" problem); and Dyadic Coping, i.e., the process how couples cope together with stress. Therefore, the aim to expand and understand these dimensions in the context of families coping with CC.
Using a three-wave longitudinal design, the investigators aim to examine (1) the role that parental we-appraisals and we-disease appraisals, couple and parent-child dyadic coping have for a child's QoL over time, (2) how these variables change over time and how these changes predict changes in a child's QoL, (3) how congruence or discrepancies within we-appraisals and we-disease-appraisals, couple and parent-child dyadic coping predict changes in child's QoL over time, and (4) how observed parental we-appraisals, partner's and parental ex-pressed emotion predict child' QoL.
The investigators expect that higher scores on parents' variables will predict positive changes on child QoL during the first 12 months after cancer diagnosis (T2 and T3). The investigators expect that changes and discrepancies within parents' variables over time will predict changes in child QoL at T2 and T3.
One hundred children with newly diagnosed cancer and their mothers and fathers will be recruited from the University Children's Hospitals in Zurich and Berne and assessed three times during 12 months. The children will be interviewed at all time points. The parents will complete several paper-pencil questionnaires assessing the variables of interest and will be interviewed at T2 (6 months) and T3 (1 year). Latent change score models with three factors (i.e. mother, father, child) and multilevel analysis will be used to test our hypothesis.
By providing precursor information about the role that key family dimensions play on explaining better child QoL over time, this study will enable health-care professionals to know which family resources and members should be targeted during cancer treatment, improve interventions and, ultimately, to improve child QoL.
|Study Type :||Observational|
|Estimated Enrollment :||300 participants|
|Official Title:||How Families Cope With Child Cancer? A Longitudinal Study on the Role of "We-appraisals" on Child's Health-related Quality of Life|
|Actual Study Start Date :||June 2015|
|Estimated Primary Completion Date :||July 2021|
|Estimated Study Completion Date :||October 2021|
- Child quality of life [ Time Frame: Three time points in a 12- months trajectory: 4/6 weeks after cancer diagnosis (T1), 6 months after diagnosis 1 (T2), and 12 months after diagnosis (T3) ]Interview based on the DISABKIDS Chronic Generic Measure long version (DCGM-37) (Ravens-Sieberer et al., 2007)
- Child posttraumatic stress disorder [ Time Frame: Three time points in a 12- months trajectory: 4/6 weeks after cancer diagnosis (T1), 6 months after diagnosis 1 (T2), and 12 months after diagnosis (T3) ]Interview based on the University of California Los Angeles Child PTSD Reaction Index (Pynoos & Steinberg, 2013, German Version Landolt, 2014)
- Parental psychological adjustment [ Time Frame: Three time points in a 12- months trajectory: 4/6 weeks after cancer diagnosis (T1), 6 months after diagnosis 1 (T2), and 12 months after diagnosis (T3) ]Measured by the Symptom-Checklist-27 (SCL-27; Hardt, Egle, Kappis, Hessel, & Brähler, 2004)
- Parental posttraumatic stress disorder [ Time Frame: Three time points in a 12- months trajectory: 4/6 weeks after cancer diagnosis (T1), 6 months after diagnosis 1 (T2), and 12 months after diagnosis (T3) ]Measured by the Posttraumatic Diagnostic Scale (PDS, German version: Elbert et al., 2014)
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02470975
|Contact: Markus Landolt, PhD||+41 44 266 73 firstname.lastname@example.org|
|Contact: Ana Vedes, PhD||+41 44 266 71 11||AnaMaria.VedesPacheco@kispi.uzh.ch|
|University Children's Hospital Zurich||Recruiting|
|Zurich, Switzerland, 8032|
|Contact: Markus Landolt, PhD +41 44 266 73 96 email@example.com|
|Sub-Investigator: Ana Vedes, PhD|
|Principal Investigator:||Markus Landolt, PhD||University Children's Hospital of Zurich|