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Trial record 93 of 126 for:    HSV-2

Review of Human Herpes Viruses in Burns

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ClinicalTrials.gov Identifier: NCT02452229
Recruitment Status : Completed
First Posted : May 22, 2015
Last Update Posted : May 22, 2015
Sponsor:
Collaborator:
Shriners Hospitals for Children
Information provided by (Responsible Party):
The University of Texas Medical Branch, Galveston

Brief Summary:
Herpes simplex virus, cytomegalovirus and varicella zoster virus infection are purported to play a pivotal role in morbidity and mortality in burns. Thus far, there is no existing systematic review (Level of Evidence III or higher) describing the unique role as well as concurrent infections of these viruses in burns. The aim of this review is to point out the clinical differences between these human herpes virus subtypes, to outline established therapy approaches, and to provide evidence for virus related morbidity and mortality in burns.

Condition or disease Intervention/treatment
Human Herpes Virus Herpes Simplex Virus Varicella-zoster Virus Chickenpox Cytomegalovirus Burns Other: Review of the Literature for Human Herpes Virus infections

Detailed Description:

This systematic review was created according the PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist.

We performed an review of the medical literature to identify all studies that contain HSV, CMV and VZV infections in burns.Therefore, systematic review of the Medline database by using PubMed and Ovid interface was conducted. Also the Web of Science interface was used for systematic literature search.

On the PubMed interface, we used the following search terms: ("HSV"[All Fields] OR "herpes"[All Fields] OR "CMV"[All Fields] OR "cytomegalovirus"[All Fields] OR "VZV"[All Fields] OR "varicella-zoster"[All Fields]) AND ("burns"[MeSH Terms] OR "burns"[All Fields] OR "burn"[All Fields] OR "thermal trauma"[All Fields]). For Ovid we used: exp Burns/ AND (exp Herpes Zoster/ or exp Encephalitis, Herpes Simplex/ or exp Herpes Simplex/ or exp Herpes Simples Virus Vaccines/), exp Burns/ AND (exp Cytomegalovirus/ or exp Cytomegalovirus Infections/), exp Burns/ AND (exp Chickenpox/ or Herpesvirus 3. Human/ or exp Herpes Zoster/). And for Web of Science we used: (TS=(HSV OR herpes OR CMV OR cytomegalovirus OR VZV OR varicella-zoster) AND TS=(burn OR burns OR thermal trauma)) AND LANGUAGE: (English) AND DOCUMENT TYPES: (Article); Timespan: All years; Indexes: SCI-EXPANDED, SSCI, A&HCI, CPCI-S.


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Study Type : Observational
Actual Enrollment : 10267 participants
Time Perspective: Retrospective
Official Title: Human Herpes Viruses in Burn Victims: A Systematic Review
Study Start Date : March 2015
Actual Primary Completion Date : May 2015

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Burns

Group/Cohort Intervention/treatment
Burn patients
The included patient are burn victims who sustained a burn of at least 1 % total body surface are (TBSA); with no restriction on age.
Other: Review of the Literature for Human Herpes Virus infections

Review of the Medline database (PubMed and Ovid interface) for human herpes virus infections in burns as well as Web of Science interface.

PRIMSA (preferred reporting items for systematic reviews and meta-analyses) guidelines and checklist were used.





Primary Outcome Measures :
  1. Prevalence of Human Herpes Virus (HHV) Infections [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months. ]
    HHV include the herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), varicella zoster virus (VZV), cytomegalovirus (CMV), Epstein-Barr viruses (EBV) and human herpes virus 6 to 8


Secondary Outcome Measures :
  1. Treatment of Human Herpes Virus (HHV) Infections [ Time Frame: Participants will be followed for the duration of hospital stay, an expected average of 3 months. ]


Information from the National Library of Medicine

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Ages Eligible for Study:   Child, Adult, Older Adult
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
Every year, about 500,000 citizens of the United States of America were burned; 50,000 of them were admitted to Burn Center. Bacterial and viral infections including cellulitis, pneumonia, wound infections and septicemia are among the top ten complications of burn injuries. Severe burn injury causes an increased inflammatory response and an overall immunosuppression. As a result severely burned patients are more prone to infections and septicemia. Early treatment of sepsis and prevention of infections are key to reducing morbidity and improving the long-term outcome of burn victims.
Criteria

Inclusion Criteria:

  • Patients who presented with at least 1% TBSA burned
  • Patients who presented with a viral infections during their hospitalization

Exclusion Criteria:

  • Patients who had no burns
  • Patients who had no viral infections during their hospitalization

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02452229


Sponsors and Collaborators
The University of Texas Medical Branch, Galveston
Shriners Hospitals for Children
Investigators
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Study Chair: David N Herndon, MD, FACS Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, Texas, USA

Publications:
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Responsible Party: The University of Texas Medical Branch, Galveston
ClinicalTrials.gov Identifier: NCT02452229     History of Changes
Other Study ID Numbers: SHC-G-SR-HHV
First Posted: May 22, 2015    Key Record Dates
Last Update Posted: May 22, 2015
Last Verified: May 2015
Additional relevant MeSH terms:
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Herpes Simplex
Chickenpox
Herpes Zoster
Burns
Virus Diseases
Wounds and Injuries
Herpesviridae Infections
DNA Virus Infections
Skin Diseases, Viral
Skin Diseases, Infectious
Skin Diseases
Varicella Zoster Virus Infection