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Trial record 6 of 20 for:    Liberia

Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL)

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ClinicalTrials.gov Identifier: NCT02448745
Recruitment Status : Completed
First Posted : May 19, 2015
Last Update Posted : May 1, 2018
Sponsor:
Collaborator:
Ministry of Health, Liberia
Information provided by (Responsible Party):
The Mentor Initiative

Brief Summary:
A cluster-randomized control trial will study the effect of insecticide-treated wall lining on malaria transmission in Bomi County, Liberia. Half of the villages enrolled in the study will receive insecticide-treated wall lining covering their walls and ceilings in addition to long-lasting insecticidal nets, while the other half will be protected by existing long-lasting insecticidal nets.

Condition or disease Intervention/treatment Phase
Malaria, Falciparum Anemia Device: Insecticide treated wall lining Not Applicable

Detailed Description:
Long-lasting insecticidal nets (LLINs) are the established vector control product for malaria control. In Bomi County Liberia, LLINs have been distributed but malaria prevalence in children under 5 remains high, with prevalence in study villages found to be 42% in April 2014. The major malaria vector species are resistant to pyrethroid insecticides approved for use in LLINs, and new control measures with non-pyrethroid active ingredients may protect the population.

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 6317 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Actual Study Start Date : March 1, 2014
Actual Primary Completion Date : June 1, 2016
Actual Study Completion Date : April 1, 2017

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Malaria

Arm Intervention/treatment
No Intervention: Control
21 clusters composed of one or more villages with a total number of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is the only malaria control intervention.
Experimental: Intervention
21 clusters composed of one or more villages with a total of 30 to 70 children under 5 years old. Routine distribution of long-lasting insecticidal nets is available and in addition insecticide treated wall lining is installed in all sleeping areas with homeowner consent. All 4 walls and the ceiling are covered with lining.
Device: Insecticide treated wall lining
Polypropylene non-woven fabric.
Other Names:
  • Durable wall lining
  • PermaNet Lining




Primary Outcome Measures :
  1. Malaria Prevalence [ Time Frame: 6 months ]
    Tested by mRDT and PCR


Secondary Outcome Measures :
  1. Hemoglobin [ Time Frame: 6 months ]
    Hemoglobin measured by Hemocue 301

  2. Fever [ Time Frame: 6 months ]
    Number of participants with Fever, defined as tympanic temperature above 37.5C

  3. Mosquito biting rate. [ Time Frame: 2 months ]
    Mosquitoes trapped indoors and outdoors using light traps and exit traps.



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Ages Eligible for Study:   2 Months to 59 Months   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Child resides in village
  • Child presents with parent or guardian

Exclusion Criteria:

  • Child or guardian has history of Ebola exposure
  • Child has 3 symptoms of Ebola

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02448745


Locations
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Liberia
Bomi County Health Team
Tubmanburg, Bomi County, Liberia
Sponsors and Collaborators
The Mentor Initiative
Ministry of Health, Liberia
Investigators
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Principal Investigator: David J Giesbrecht, MSc Study Coordinator

Additional Information:
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Responsible Party: The Mentor Initiative
ClinicalTrials.gov Identifier: NCT02448745     History of Changes
Other Study ID Numbers: LiberiaDL
First Posted: May 19, 2015    Key Record Dates
Last Update Posted: May 1, 2018
Last Verified: April 2018
Additional relevant MeSH terms:
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Malaria, Falciparum
Malaria
Protozoan Infections
Parasitic Diseases