Cardiac Toxicity in Medical Treatment of Breast Cancer (CaTOB)
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|ClinicalTrials.gov Identifier: NCT02440620|
Recruitment Status : Completed
First Posted : May 12, 2015
Last Update Posted : May 1, 2019
This study will describe the epidemiology including prognosis of heart failure related to treatment with anthracycline and trastuzumab for breast cancer.
In a prospective study Human Epidermal Growth Factor Receptor 2 (HER2) positive breast cancer patients scheduled for trastuzumab treatment at Odense University Hospital, will be offered advanced echocardiographic examination, test of bio-markers and genetic markers for the purpose of investigating if early identification of patients in particular risk of developing heart failure is feasible.
|Condition or disease|
|Heart Failure Breast Cancer|
|Study Type :||Observational|
|Actual Enrollment :||45 participants|
|Official Title:||Cardiac Toxicity in Medical Treatment of Breast Cancer|
|Actual Study Start Date :||October 2014|
|Actual Primary Completion Date :||August 2018|
|Actual Study Completion Date :||August 2018|
- Global longitudinal strain by two dimentional speckle tracking. [ Time Frame: Change in outcome from initiation of trastuzumab treatment and after 3,6, and 9 month. ]
- Ratio between the mitral E velocity and early diastolic maximum global strain rate (E/SRE). [ Time Frame: Change in outcome from initiation of trastuzumab treatment and after 3,6, and 9 month. ]
Biospecimen Retention: Samples With DNA
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02440620
|Odense University Hospital|
|Odense c, Denmark, 5000|
|Study Director:||Jacob Moeller, MD, DMsc||Odense University Hospital|