Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine
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|ClinicalTrials.gov Identifier: NCT02430272|
Recruitment Status : Completed
First Posted : April 30, 2015
Last Update Posted : May 1, 2015
Anticholinergic drugs have traditionally been used for their antisialagogue properties. But use of anticholinergic drugs can interfere with thermoregulation via inhibition of the parasympathetically mediated sweat secretion. Sweating inhibition can reduce heat elimination, and children's thermoregulation depend more on sweating than adults and they can become hyperthermic when given these agents.
The investigators evaluated the fever-causing effects of adjunctive anticholinergics in children under general anesthesia using ketamine.
|Condition or disease||Intervention/treatment||Phase|
|Fever||Drug: Glycopyrrolate||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||84 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)|
|Official Title:||Anticholinergic Premedication Induced Fever in Pediatric Ambulatory Anesthesia With Ketamine|
|Study Start Date :||May 2014|
|Actual Primary Completion Date :||November 2014|
|Actual Study Completion Date :||December 2014|
Experimental: Anticholinergic premedication
Premedication with 0.005mg/Kg of glycopyrrolate
Intravenously administered 0.005mg/Kg of glycopyrrolate in intervention group
No Intervention: Control group
Same volume of normal saline
- Body temperature [ Time Frame: every 30 minutes from base line ( up to 90min ) ]measured body temperature at three times in both ears and the highest value was selected.
- Oral secretion (VAS) [ Time Frame: up to operative end ]Oral secretion during the whole procedure was recorded by the researcher
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Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02430272
|Korea, Republic of|
|Ilsan Paik hospital|
|Goyang-si, Gyeonggi-do, Korea, Republic of, 411-706|
|Study Chair:||Won Joo Choe, M.D. Ph.D||Inje Univ.|