Corneal Changes After Crosslinking in Keratoconus Patients Compared to the Untreated Fellow Eye
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government.
Read our disclaimer for details.
ClinicalTrials.gov Identifier: NCT02428166
Recruitment Status :
First Posted : April 28, 2015
Last Update Posted : December 13, 2017
Information provided by (Responsible Party):
Prof. Dr. med. Mike P. Holzer, Heidelberg University
The purpose of this retrospective study is to assess corneal changes (keratometry, pachymetry) and change in visual acuity (VA) in keratoconus patients after unilateral crosslinking treatment compared to the untreated fellow eye. The corneal measurements obtained preoperatively and 2 to 14 months postoperatively using a Pentacam rotating scheimpflug camera are analyzed. Furthermore, pre-existing or actual ocular pathology or/and ocular surgeries as potential factors involved in treatment outcome are also evaluated.
Change in maximum keratometry (Kmax) as measured by the Pentacam HR [ Time Frame: after completion of data collection based on the measurements preoperatively and 2-14 months postoperative ]
Secondary Outcome Measures :
Change in corneal thickness as measured by the Pentacam HR [ Time Frame: retrospective analysis from preoperatively to 2-14 months postoperatively ]
Change in visual acuity (VA) [ Time Frame: retrospective analysis from preoperatively to 2-14 months postoperatively ]
Evaluation of pre-existing ocular pathology or/and ocular surgery as potential factors involved in treatment outcome [ Time Frame: retrospective analysis from preoperatively to 2-14 months postoperatively ]
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.
Layout table for eligibility information
Ages Eligible for Study:
18 Years to 50 Years (Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Eligible keratoconus patients aged 18-50 years who underwent unilateral crosslinking treatment in our ophthalmology department and completed a postoperative follow-up of 2-14 months
Keratoconus patients after unilateral crosslinking treatment
Morphological changes of the cornea caused be ocular infection or trauma (e.g. corneal scarring)
Other pre-existing corneal surgery (e.g. corneal transplantation, implantation of intrastromal corneal ring segments)