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A Comparison Between the Aysis® Cs2 (General Electrics) Ventilator in EtControl® Mode and the Perseus® A 500 (Dräger) in VaporView® Mode on Maniability and Consumption of Desflurane (ConsoHalo)

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ClinicalTrials.gov Identifier: NCT02427971
Recruitment Status : Unknown
Verified April 2015 by Bonnot, Saint Antoine University Hospital.
Recruitment status was:  Recruiting
First Posted : April 28, 2015
Last Update Posted : April 28, 2015
Sponsor:
Information provided by (Responsible Party):
Bonnot, Saint Antoine University Hospital

Brief Summary:

The Aysis® Cs2 ventilator offers an automated control of end-tidal inhalation anesthetic concentration, the EtControl® mode. A low Fresh Gas Flow (FGF) (0.5L/min) is kept during the maintenance of the anesthesia, decreasing the expensive consumption of halogenated agents.

The Perseus® A 500 offers a VaporView® mode that gives the evolution of inspired (Fi) and end-tidal (Fe) fractions of halogenated agents for 20 minutes based on the delivered fraction (Fd). FGF remains adjusted manually by the practitioner. This mode also makes it possible to maintain a low FGF (0.5 L/min), provided the halogen Fd is set to maintain a steady Fe curve.

The goal of this work was to compare the maniability of the intraoperative administered concentrations and the consumption of Desflurane between these 2 modalities of administration.


Condition or disease
Anesthetics Agent Consumption Inhalation Desflurane

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Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: A Comparison Between the Aysis® Cs2 (General Electrics) Ventilator in EtControl® Mode and the Perseus® A 500 (Dräger) in VaporView® Mode on Maniability and Consumption of Desflurane
Study Start Date : January 2015
Actual Primary Completion Date : April 2015
Estimated Study Completion Date : April 2015

Group/Cohort
Perseus
Use of Perseus® A 500 with VaporView® mode that gives the evolution of inspired (Fi) and end-tidal (Fe) fractions of halogenated agents for 20 minutes based on the delivered fraction (Fd). FGF remains adjusted manually by the practitioner. This mode also makes it possible to maintain a low FGF (0.5 L/min)
Aysis
Use of Aysis® Cs2 ventilator with automated control of end-tidal inhalation anesthetic concentration, EtControl® mode.



Primary Outcome Measures :
  1. Consumption of Desflurane between these 2 modalities of administration. [ Time Frame: Time of general anesthesia (1h minimum up to 12h) ]
    Des consumption was measured by micrometric weighing of the vaporizer before and after general anesthesia and a milliliter per min consumption was calculated


Secondary Outcome Measures :
  1. Comparison of inspired (Fi) and end-tidal (Fe) fractions of halogenated evolution [ Time Frame: Time of general anesthesia (1h minimum up to 12h) ]
  2. Anesthesia depth monitoring by BIS [ Time Frame: Time of general anesthesia (1h up to 12h) ]
  3. Hemodynamic stability [ Time Frame: Time of general anesthesia (1h minimum up to 12h) ]

    Number of cardiovascular event which required an intervention

    • Vasopressive drug
    • Antihypertensive drug
    • modification of the Desflurane end-tidal (Fe) fraction



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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
ASA 1/2 adult patients undergoing a general anesthesia of more than one hour.
Criteria

Inclusion Criteria:

  • patients undergoing a general anesthesia for intra abdominal surgery during more than one hour
  • ASA 1or 2

Exclusion Criteria:

  • contraindication to halogenated agent
  • thoracic surgery
  • no french speaking

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02427971


Locations
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France
Hôpital Saint-Antoine Recruiting
Paris, France
Contact: Christophe Gutton       christophe.gutton@sat.aphp.fr   
Sponsors and Collaborators
Saint Antoine University Hospital
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Responsible Party: Bonnot, MD, Saint Antoine University Hospital
ClinicalTrials.gov Identifier: NCT02427971    
Other Study ID Numbers: 2014-A01476-41
First Posted: April 28, 2015    Key Record Dates
Last Update Posted: April 28, 2015
Last Verified: April 2015
Additional relevant MeSH terms:
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Respiratory Aspiration
Respiration Disorders
Respiratory Tract Diseases
Pathologic Processes