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Optimal Low B-value in Intravoxel Incoherent Motion Diffusion-weighted MR Imaging of the Brain

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ClinicalTrials.gov Identifier: NCT02411864
Recruitment Status : Completed
First Posted : April 8, 2015
Last Update Posted : July 5, 2017
Sponsor:
Information provided by (Responsible Party):
Tang-Du Hospital

Brief Summary:
Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

Condition or disease Intervention/treatment
Healthy Volunteers Other: different low b-values distribution

Detailed Description:
As an improved MRI technique, diffusion-weighted imaging (DWI) is considered the most sensitive for early pathological changes. Perfusion measurement has been shown to improve sensitivity and predictive value for tumor grading and prognosis, also as a predicator of recovery with reperfusion in patients of acute ischemic stroke.Our research aims to reveal whether the low b-values distribution and the number of NEX for each b value will influence the accuracy of pseudodiffusion parameter derived from IVIM in brain.

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Study Type : Observational
Actual Enrollment : 20 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Can the Distribution of Low B-value and the NEX Influence the Pseudodiffusion Parameter Derived From IVIM in Brain?
Study Start Date : November 2014
Actual Primary Completion Date : December 2014
Actual Study Completion Date : December 2014

Group/Cohort Intervention/treatment
Group 1
Low b=(0,50,150,200),NEX=(1,3,2,2)
Other: different low b-values distribution
Group 2
Low b=(0,30,50,100,200),NEX=(1,3,3,2,2)
Other: different low b-values distribution
Group 3
Low b=(0,30,60,90,120,150,180,200),NEX=(1,3,3,3,2,2,2,2)
Other: different low b-values distribution
Group 4
Low b=(0,30,60,90,120,150,180,200),NEX=(1,1,1,1,1,1,1,1)
Group 5
Low b=(0,20,40,60,80,100,120,140,160,180,200)NEX=(1,3,3,3,3,2,2
Other: different low b-values distribution



Primary Outcome Measures :
  1. Parameters D* and f in healthy white matter or gray mater [ Time Frame: 2-3 days ]


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Ages Eligible for Study:   25 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
healthy volunteers
Criteria

Inclusion Criteria:

  • no hypertension or cerebral vascular diseases,
  • no systemic metabolic disease;
  • no infection or fever;
  • no use of corticosteroid drugs;
  • no MRI contraindication.

Exclusion Criteria:


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Responsible Party: Tang-Du Hospital
ClinicalTrials.gov Identifier: NCT02411864     History of Changes
Other Study ID Numbers: TDLL-20140570
First Posted: April 8, 2015    Key Record Dates
Last Update Posted: July 5, 2017
Last Verified: July 2017

Keywords provided by Tang-Du Hospital:
IVIM
brain
diffusion-weighted imaging