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Myocardial and Cerebral Dysfunction by Oxidative Stress Caused by On-pump Surgery

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ClinicalTrials.gov Identifier: NCT02394405
Recruitment Status : Unknown
Verified March 2015 by Oleg A. Grebenchikov, Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy.
Recruitment status was:  Not yet recruiting
First Posted : March 20, 2015
Last Update Posted : March 20, 2015
Sponsor:
Information provided by (Responsible Party):
Oleg A. Grebenchikov, Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy

Brief Summary:
Assessment of the severity of oxidative stress caused by the on-pump and off-pump CAGB using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.

Condition or disease
Reperfusion Injury

Study Type : Observational
Estimated Enrollment : 60 participants
Observational Model: Cohort
Time Perspective: Retrospective
Official Title: Myocardial and Cerebral Dysfunction by Oxidative Stress Caused by On-pump Surgery
Study Start Date : March 2015
Estimated Primary Completion Date : March 2015
Estimated Study Completion Date : October 2015

Group/Cohort
on-pump surgery
off-pump surgery



Primary Outcome Measures :
  1. Assay of mtDNA [ Time Frame: from baseline whithin 72 H ]

Secondary Outcome Measures :
  1. Assay of nDNA [ Time Frame: from baseline whithin 72 H ]
  2. Assay of carbonilated proteins [ Time Frame: from baseline whithin 72 H ]
  3. Assay of nitrotyrosine [ Time Frame: from baseline whithin 72 H ]
  4. Assay of oxy-LDL [ Time Frame: from baseline whithin 72 H ]
  5. Assay of S100b-protein [ Time Frame: from baseline whithin 72 H ]


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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population
primary care clinic
Criteria

Inclusion Criteria:

  • shedduled CABG

Exclusion Criteria:

  • stroke befor surgery
  • miocardial infarction 6 monthes befor surgery
  • dementia
  • liver cirrhosis

Responsible Party: Oleg A. Grebenchikov, senior researcher, Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
ClinicalTrials.gov Identifier: NCT02394405     History of Changes
Other Study ID Numbers: OD-CABG-2015
First Posted: March 20, 2015    Key Record Dates
Last Update Posted: March 20, 2015
Last Verified: March 2015

Additional relevant MeSH terms:
Reperfusion Injury
Vascular Diseases
Cardiovascular Diseases
Postoperative Complications
Pathologic Processes