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Metabolic Cost of Sitting, Standing, and Transitions

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ClinicalTrials.gov Identifier: NCT02377037
Recruitment Status : Completed
First Posted : March 3, 2015
Last Update Posted : March 3, 2015
Sponsor:
Information provided by (Responsible Party):
Analiza M Silva, PhD, Technical University of Lisbon

Brief Summary:

There is already a lot of scientific evidence supporting the benefits of public health recommendations regarding physical activity (the accumulation of at least 150 minutes of at least moderate intensity physical activity per week). However, these 30 daily minutes represent only about 3% of the waking period. Recent data suggest that most of the population spends on average 8-9 hours / day of sedentary behavior (SB). SB is characterized by any activity with a metabolic cost (MC) below 1.5 METs, mainly actions in the sitting position. In fact, there is evidence that the more time spent sitting higher the risk of disease and mortality, with sitting directly associated with diseases such as type II diabetes, cardiovascular diseases and even cancer. The average life expectancy may increase by ~ 2 years if the investigators reduce sitting about 3h/ day. Additionally, how people accumulate sitting time seems to be a major factor, with prolonged sitting associated with a higher risk of disease. Short-term experimental studies indicate that sedentary lifestyles affect energy balance enhancing weight gain. While there is some research regarding the MC associated with "sitting" and "standing" behaviors, the results are contradictory. Besides these conflicting results, the impact of transitions between these two types of behavior and how these transitions can contribute to MC increase have never been investigated.

Our hypothesis is that, in both men and women, the simple replacement of sitting for "standing" may not substantially increase MC, but instead, the largest contribution may reside on the transitions between these two states of behavior. Therefore, the investigators will perform a study with the following purposes:

Examine MC and HR associated with "sitting", "standing", and transitions between these two types of behavior in adults of both gender, apparently healthy with variable body composition profiles.


Condition or disease Intervention/treatment Phase
Metabolic Cost Other: Metabolic cost and HR associated with distinct postural behaviors Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 50 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: None (Open Label)
Primary Purpose: Basic Science
Official Title: What is the Metabolic Cost of Sitting, Standing, and Sit/Stand Transitions? A Randomized Controlled Trial
Study Start Date : November 2014
Actual Primary Completion Date : February 2015
Actual Study Completion Date : February 2015

Arm Intervention/treatment
Experimental: Sitting
Remain seated in a chair, with hands placed on top of the thighs for 10 minutes, remaining motionless in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured minute by minute.
Other: Metabolic cost and HR associated with distinct postural behaviors
The order of the three conditions will be randomly assigned and all will be undertaken in laboratory settings. Before engaging in the experimental conditions participants will perform anthropometric and body composition assessments and also the resting EE evaluation. All evaluations will be performed at one time only, starting at 7:00 am in the morning after an overnight fast

Experimental: Standing
Remain in an upright position (standing) with hands placed on the thighs for 10 minutes, remaining motionless in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured minute by minute.
Other: Metabolic cost and HR associated with distinct postural behaviors
The order of the three conditions will be randomly assigned and all will be undertaken in laboratory settings. Before engaging in the experimental conditions participants will perform anthropometric and body composition assessments and also the resting EE evaluation. All evaluations will be performed at one time only, starting at 7:00 am in the morning after an overnight fast

Experimental: Transitions sit/stand
The participant will perform one sit-to-stand followed by a stand-to-sit transition, every minute in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured.
Other: Metabolic cost and HR associated with distinct postural behaviors
The order of the three conditions will be randomly assigned and all will be undertaken in laboratory settings. Before engaging in the experimental conditions participants will perform anthropometric and body composition assessments and also the resting EE evaluation. All evaluations will be performed at one time only, starting at 7:00 am in the morning after an overnight fast




Primary Outcome Measures :
  1. Metabolic cost [ Time Frame: 60 minutes (30 from metabolic rest and 30 from conditions) ]
    The MC will be estimated using an open-circuit spirometry system (MedGraphics Corporation, Breezeex Software). Each participant will have to complete 4 periods (conditions) of 10 minutes in which the calorimeter device is attached to the mask and breath-by-breath VO2 and VCO2 are measured for 40 minutes.


Secondary Outcome Measures :
  1. Heart rate [ Time Frame: 60 minutes (30 from metabolic rest and 30 from conditions) ]
    Heart rate will be measured continuously using a pulse oximeter that is attached to the MedGraphics system. This is a medical device that indirectly monitors the oxygen saturation of a patient's blood (as opposed to measuring oxygen saturation directly through a blood sample). Heart rate and oxygen consumption data will be analyzed minute-by-minute.



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Ages Eligible for Study:   18 Years to 64 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Men and women aged 18-64 years and without major metabolic, pulmonary, and cardiac disorders and general health guaranteed.
  • Physically independent and able to perform all the conditions without limitations.

Exclusion Criteria:

  • Pregnancy or engagement in any weight loss program that may affect energy balance.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02377037


Locations
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Portugal
Exercise and Health Laboratory, Faculdade de Motricidade Humana, Universidade de Lisboa
Cruz Quebrada, Lisboa, Portugal, 1495
Sponsors and Collaborators
Technical University of Lisbon
Investigators
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Principal Investigator: Analiza M Silva, PhD Laboratory of Exercise and Health, Faculadde Motricidade Humana, Universidade de Lisboa
Publications:
Lohman TG, Roche AF, Martorell R (1988) Anthropometric standardization reference manual. Champaign, IL: Human Kinetics Publichers.

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Responsible Party: Analiza M Silva, PhD, Professor, Technical University of Lisbon
ClinicalTrials.gov Identifier: NCT02377037    
Other Study ID Numbers: Transitions study
First Posted: March 3, 2015    Key Record Dates
Last Update Posted: March 3, 2015
Last Verified: February 2015
Keywords provided by Analiza M Silva, PhD, Technical University of Lisbon:
Sitting
Standing
Transitions