Effects of Isoflavone Combined With Astaxanthin on Skin Aging
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|ClinicalTrials.gov Identifier: NCT02373111|
Recruitment Status : Completed
First Posted : February 26, 2015
Last Update Posted : June 14, 2016
Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) play a key role in UV-induced skin damage and diminish skin matrix protein levels, leading skin aging. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.
Astaxanthin mainly from marine algae and crustaceans is a kind of carotenoids which were well-known photo-protective agents with strong antioxidant activity. Several studies have revealed that supplementation of astaxanthin effectively protect skin against UV damage through free radicals.
In addition, matrix metalloproteinase-1 induced by UV irradiation is an important step toward skin aging. Recently, many studies pointed out that phytoestrogens exhibit agonistic and antagonistic estrogen activities, suppressing activity of MMP-1 in skin. Isoflavone is a kind of phytoestrogen from soybean and mainly act on skin and bones, inhibiting MMP-1 effectively.
The present study is designed to take isoflavone combined with astaxanthin to maximize their anti-aging ability and objectively measure the effects of the mixture on facial wrinkles, hydration, and elasticity.
|Condition or disease||Intervention/treatment||Phase|
|Ageing Photo-aging||Dietary Supplement: Isoflavone Dietary Supplement: Astaxanthin Dietary Supplement: Placebo||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||90 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||Double (Participant, Investigator)|
|Official Title:||Effects of Isoflavone Combined With Astaxanthin on Skin Aging|
|Study Start Date :||March 2015|
|Actual Primary Completion Date :||November 2015|
|Actual Study Completion Date :||December 2015|
Active Comparator: Isoflavone and Astaxanthin
Each subject takes one active tablet per day for 24 weeks. Each tablet contains isoflavone 27mg and astaxanthin 4mg.
Dietary Supplement: Isoflavone
Dietary Supplement: Astaxanthin
Placebo Comparator: Placebo
Each subject takes one placebo tablet per day for 24 weeks.
Dietary Supplement: Placebo
- Change from baseline in skin wrinkles [ Time Frame: Twenty-four weeks ]Facial wrinkles in the crow's feet area measured by Skin Visiometer
- Change from baseline in skin elasticity [ Time Frame: Twenty-four weeks ]Facial elasticity measured by Cutometer
- Change from baseline in epidermal hydration [ Time Frame: Twenty-four weeks ]Skin hydration measured by Corneometer
- Change from baseline in skin barrier integrity [ Time Frame: Tewnty-four weeks ]TEWL measured by Tewameter
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02373111
|Korea, Republic of|
|Seoul National University Hospital|
|Seoul, Korea, Republic of, 110744|
|Principal Investigator:||Jin Ho Chung, MD, PhD||Seoul National University Hospital|