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Trial record 1 of 1 for:    02364427 | Acute Kidney Injury
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Arterial Stiffness and AKI Post-CABG (Heart-AKI)

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ClinicalTrials.gov Identifier: NCT02364427
Recruitment Status : Completed
First Posted : February 18, 2015
Last Update Posted : March 11, 2019
Sponsor:
Information provided by (Responsible Party):
King's College Hospital NHS Trust

Brief Summary:
Acute Kidney Injury is a condition where your kidneys suddenly stop working properly and usually occurs if you are already unwell with an illness and can happen after having surgery. Having an episode of acute kidney injury increases the risk of progression to chronic kidney disease (CKD) later on and decreases long-term survival. It also has a major socioeconomic impact with regards to admissions and length of hospital stay. There is currently no universally accepted treatment or method of identifying patients that are at risk. The investigators aim to measure arterial stiffness in patients prior to them undergoing cardiac surgery to investigate whether this measurement is associated with an increased risk of patients developing acute kidney injury after surgery. The investigators are planning to measure arterial stiffness, and examine a blood sample, for kidney health-related levels to determine whether there is an association between those patients who have stiff arterial vessels and those patients who may develop acute kidney injury after surgery.

Condition or disease Intervention/treatment
Acute Kidney Injury Device: Arterial stiffness - Vicorder to measure pulse wave velocity

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Study Type : Observational
Actual Enrollment : 180 participants
Observational Model: Cohort
Time Perspective: Prospective
Official Title: Arterial Stiffness and Acute Kidney Injury Post-Coronary Artery Bypass Graft Surgery
Actual Study Start Date : April 2015
Actual Primary Completion Date : September 2018
Actual Study Completion Date : September 2018

Resource links provided by the National Library of Medicine


Group/Cohort Intervention/treatment
Arterial stiffness
Arterial stiffness - Vicorder to measure pulse wave velocity
Device: Arterial stiffness - Vicorder to measure pulse wave velocity
Pulse wave velocity (PWV)measures the stiffness of the arteries. This provides a simple and quick noninvasive method of obtaining the PWV for an arterial segment.
Other Name: Vicorder




Primary Outcome Measures :
  1. Pulse Wave Velocity (arterial stiffness) [ Time Frame: Baseline visit ]

Secondary Outcome Measures :
  1. Kidney function measured by renal blood profile [ Time Frame: baseline ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
All patients undergoing pure (non-valvular repair) CABG surgery
Criteria

Inclusion Criteria:

  • All patients undergoing pure (non-valvular repair) CABG surgery
  • Male or female
  • Aged >18 years
  • Written informed consent

Exclusion Criteria:

  • Patients who have aortic grafts or renal stents
  • Patients at CKD stage 4 or 5 or on dialysis
  • Bilateral amputee
  • Unable to lie supine for 10-15 mins
  • Psychiatric illness, including anxiety, mood and untreated eating disorders
  • Infection or course of antibiotics within the last month

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT02364427


Locations
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United Kingdom
King's College Hospital
London, United Kingdom, SE5 9RS
Sponsors and Collaborators
King's College Hospital NHS Trust
Investigators
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Principal Investigator: Sharlene A Greenwood, PhD Consultant renal physiotherapist
Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
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Responsible Party: King's College Hospital NHS Trust
ClinicalTrials.gov Identifier: NCT02364427    
Other Study ID Numbers: KCH heart-AKI
First Posted: February 18, 2015    Key Record Dates
Last Update Posted: March 11, 2019
Last Verified: March 2018
Keywords provided by King's College Hospital NHS Trust:
Pulse wave velocity
Arterial stiffness
AKI
Additional relevant MeSH terms:
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Acute Kidney Injury
Renal Insufficiency
Kidney Diseases
Urologic Diseases