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The Impact of Sucrose Ingestion Post-Exercise on Liver and Muscle Glycogen Repletion.

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT02344381
Recruitment Status : Completed
First Posted : January 26, 2015
Last Update Posted : October 23, 2015
Maastricht University
Newcastle University
Sugar Nutrition
Information provided by (Responsible Party):
Northumbria University

Brief Summary:

Carbohydrate is stored in the body as glycogen, which is mainly found in the liver and muscle. During endurance exercise, muscle glycogen is used as fuel for the working muscles and liver glycogen is broken down to provide glucose to maintain blood glucose (sugar) levels. Both liver and muscle glycogen are important for our ability to perform intense/prolonged endurance exercise. Therefore, it is important to replete these stores after an intense/prolonged endurance exercise session in order to recover and perform optimally during a subsequent exercise bout, especially if the next exercise session is within 24h (e.g. stage races such as the Tour de France, tournament-style competitions such as the Olympic games and ultra-endurance events).

Carbohydrate intake has been shown to increase the availability of glycogen in the muscle and liver after exercise. The carbohydrates typically found in sports drinks are glucose and sometimes fructose. It has been observed that the ingestion of glucose will lead to a maximum rate of absorption of approximately ~1 g/min. However, if we also provide a different source of carbohydrate (fructose) then this is absorbed through a different pathway and therefore we can absorb up to ~1.75 g/min of carbohydrate. In addition, both carbohydrate sources are metabolised differently in the human body. By supplementing both glucose and fructose, we can potentially replenish the liver and muscle glycogen stores at a faster rate than ingestion of glucose only.

Sucrose is a naturally occurring sugar that is made up of a single glucose and single fructose molecule. Therefore, theoretically, this can use the two different pathways of absorption and also maximise carbohydrate delivery. It is not yet known however, what impact this has on our liver and muscle glycogen stores post-exercise when supplemented in relatively high amounts. Therefore the aim of this study is to assess whether relative high amounts of sucrose ingestion will improve liver and muscle glycogen repletion after endurance exercise.

Condition or disease Intervention/treatment Phase
Liver and Muscle Glycogen Replenishment Post-exercise Dietary Supplement: Sucrose Dietary Supplement: Glucose Not Applicable

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Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 15 participants
Allocation: Randomized
Intervention Model: Crossover Assignment
Masking: Double (Participant, Investigator)
Primary Purpose: Basic Science
Study Start Date : January 2015
Actual Primary Completion Date : May 2015
Actual Study Completion Date : May 2015

Resource links provided by the National Library of Medicine

Drug Information available for: Sucrose

Arm Intervention/treatment
Experimental: Sucrose
Sucrose ingestion post-exercise
Dietary Supplement: Glucose
Active Comparator: Glucose
Glucose ingestion post-exercise
Dietary Supplement: Sucrose

Primary Outcome Measures :
  1. change in liver glycogen concentration [ Time Frame: 5 h ]
    The change in liver glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

Secondary Outcome Measures :
  1. Change in muscle glycogen concentration [ Time Frame: 5 h ]
    The change in muscle glycogen content will be determined post-exercise using 13C magnetic resonance spectroscopy

  2. Plasma glucose concentration [ Time Frame: 5 h ]
  3. Plasma insulin concentration [ Time Frame: 5 h ]
  4. Plasma lactate concentration [ Time Frame: 5 h ]

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 35 Years   (Adult)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Healthy
  • Endurance trained cyclists/triathletes
  • VO2 max ≥ 50 ml/kg/min

Exclusion Criteria:

  • Use of medication
  • Smoking
  • Metabolic disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT02344381

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United Kingdom
Northumbria University
Newcastle upon Tyne, North East, United Kingdom, NE1 8ST
Sponsors and Collaborators
Northumbria University
Maastricht University
Newcastle University
Sugar Nutrition
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Principal Investigator: Luc van Loon, PhD Maastricht University

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Responsible Party: Northumbria University Identifier: NCT02344381     History of Changes
Other Study ID Numbers: NorthumbriaU
First Posted: January 26, 2015    Key Record Dates
Last Update Posted: October 23, 2015
Last Verified: October 2015